Foamy histiocytosis of the spleen in patients with chronic thrombocytopenia.
Foamy histiocytosis of the spleen in patients with chronic thrombocytopenia.
复制标题
慢性血小板减少症患者的脾脏泡沫状组织细胞增多症。
DOI：
10.1111/j.1600-0609.1976.tb01113.x
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
I. Tygstrup
中科院分区：
文献类型：
--
作者：
J. Cohn;I. Tygstrup
从慢性血小板减少症患者身上摘取的 64 个脾脏中，有 17 个脾脏中存在富含脂质的组织细胞。这些病理结果与诊断或脾切除时患者的年龄、脾切除前糖皮质激素治疗的持续时间、血小板减少的时间或血小板计数之间没有发现相关性。脾切除后复发的 7 名患者的脾脏中有富含脂质的组织细胞，即复发患者的 58%，相比之下，有 10 名患有泡沫状组织细胞增多症但未复发的患者，即未复发患者的 19%。随访时，17 名脾组织细胞增多症患者中有 3 名仍出现血小板减少症，而 47 名无泡沫细胞的患者中有 1 名出现血小板减少。慢性血小板减少症患者的脾脏泡沫状组织细胞增多症可能表明预后可疑。
In 17 of the 64 spleens removed from patients with chronic thrombocytopenia lipid-laden histiocytotes were demonstrated. No correlation was found between these pathological findings and the age of the patients at diagnosis or splenectomy, the duration before splenectomy of therapy with glucocorticoids, the period with thrombocytopenia or the platelet count. 7 of the patients, who relapsed after splenectomy had lipid-laden histiocytes in their spleens i.e. 58% of the patients with relapse, compared with 10 patients with foamy histiocytosis and without relapse i.e. 19% of the patients without relapse. At follow up, 3 of the 17 patients with splenic histiocytosis still had thrombocytopenia, compared with 1 of the 47 patients without foamy cells. Foamy histiocytosis of the spleen from a patient with chronic thrombocytopenia may indicate a dubious prognosis.