Basal ganglia are active during motor performance recovery after a demanding motor task
Basal ganglia are active during motor performance recovery after a demanding motor task
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DOI：
10.1016/j.neuroimage.2012.10.012
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发表时间：
2013-01-15
期刊：
影响因子：
5.7
通讯作者：
Bove, Marco
中科院分区：
文献类型：
--
作者：
Bonzano, Laura;Tacchino, Andrea;Bove, Marco
在高要求的手指运动任务后，运动表现的恢复并不遵循初级运动皮层（M1）的兴奋性动力学，当运动表现恢复时，初级运动皮层仍处于低迷状态。因此，其他神经回路应该应对中枢疲劳，重新建立足够的运动表现水平。研究表明中枢疲劳与基底神经节相关，提示基底神经节（BG）可能参与这一过程。为了研究这种可能性，我们对20名健康志愿者进行了fMRI研究，同时记录了他们在不同阶段的运动表现：基线、5分钟序列重复引起的中枢疲劳、短时间休息后的表现恢复。当运动能力恢复时，我们观察到属于不同BG回路（壳核和苍白球）的皮质下结构相对于基线有显著的激活，涉及边缘系统与BC（杏仁核）的功能相互作用。然后，为了评估BC激活是否只与疲劳和恢复过程有关，还是与运动表现的自动性增加有关，我们对14名健康受试者进行了一项基于较短运动任务持续时间的对照fMRI实验。在这种情况下，任务重复不会导致性能下降，并且相对于基线，在BC感兴趣的区域中没有发现对BOLD信号变化的显著影响。所有这些研究结果表明，运动和非运动BC电路并行运行，并在共同的运动路径上收敛，以成功补偿中央疲劳状态下的运动性能下降。(C) 2012爱思唯尔公司版权所有。
Motor performance recovery after a demanding finger motor task does not follow the excitability dynamics of primary motor cortex (M1), which remains depressed also when performance is restored. Thus, other neural circuits are supposed to cope with central fatigue, re-establishing adequate motor performance levels. A hint that the basal ganglia (BG) can be involved in this process is provided by studies showing an association of central fatigue with the BG. To investigate this possibility, we conducted an fMRI study with simultaneous motor performance recording in 20 healthy volunteers at different stages of a demanding finger motor task: baseline, central fatigue induced by 5-min sequence repetition, performance recovery after a short rest period.When motor performance was recovered, we observed a significant activation with respect to baseline in subcortical structures belonging to different BG circuits (putamen and globus pallidus), involving the limbic system functionally interacting with the BC (amygdala). Then, to assess whether the BC activation was exclusively related to the fatigue and recovery processes or to increasing automatism in motor performance, a control fMRI experiment based on a shorter motor task duration was carried out on 14 healthy subjects. In this case, the task repetition did not induce decreased performance, and no significant effect on the BOLD signal change was found in BC regions of interest with respect to baseline.All these findings suggest that motor and non-motor BC circuits run parallel and converge in a common motor path to successfully compensate motor performance deterioration in a central fatigue condition. (C) 2012 Elsevier Inc. All rights reserved.