Euphorhelipanes A and B, Triglyceride-Lowering Euphorbia Diterpenoids with a Bicyclo[4.3.0]nonane Core from Euphorbia helioscopia
Euphorhelipanes A and B, Triglyceride-Lowering Euphorbia Diterpenoids with a Bicyclo[4.3.0]nonane Core from Euphorbia helioscopia
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大戟 A 和 B，具有来自大戟的双环[4.3.0]壬烷核心的降低甘油三酯的大戟二萜类化合物
DOI：
10.1021/acs.jnatprod.8b00780
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发表时间：
2019
影响因子：
5.1
通讯作者：
Yin Sheng
中科院分区：
文献类型：
--
作者：
Li Wei;Tang Ya Qi;Chen Shi Xin;Tang Gui Hua;Gan Li She;Li Chan;Rao Yong;Huang Zhi Shu;Yin Sheng
从泽漆（Euphorbia helisopia）全草的95%乙醇提取物中分离得到两个具有新骨架的泽漆双二萜类化合物Euphorhelipanes A（1）和B（2）。通过光谱数据分析、量子化学计算和单晶X射线衍射数据确定了它们的结构。化合物1和2代表了第一个具有5/6稠合碳环系统的大戟二萜类化合物的实例，并提出了它们可能的生物合成途径，起源于jatrophanes。化合物1和2在1-50 μM的浓度下在油酸刺激的HuH 7细胞中显示出降低甘油三酯的作用。
Euphorhelipanes A (1) and B (2), twoEuphorbiaditerpenoids with a new 4-(5,5-dimethylheptan-2-yl)-2,7-dimethylbicyclo[4.3.0]nonane skeleton, were isolated from a 95% ethanol extract of the whole plants ofEuphorbia helioscopia. Their structures were elucidated by spectroscopic data analysis, quantum chemical calculations, and single-crystal X-ray diffraction data. Compounds1and2represent the first examples ofEuphorbiaditerpenoids with a 5/6 fused carbon ring system, and their plausible biosynthetic pathways originating from jatrophanes are proposed. Compounds1and2showed a triglyceride-lowering effect in oleic-acid-stimulated HuH7 cells at concentrations of 1–50 μM.