Role of matrix metalloproteinases in dental caries, pulp and periapical inflammation: An overview.
Role of matrix metalloproteinases in dental caries, pulp and periapical inflammation: An overview.
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DOI：
10.1016/j.jobcr.2015.06.015
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发表时间：
2015-09-01
影响因子：
--
通讯作者：
Bahuguna, Rachana
中科院分区：
文献类型：
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作者：
Jain, Atul;Bahuguna, Rachana
基质金属蛋白酶(MMPs)是一组超过25种分泌型和膜结合型的酶，它们代表了一类负责降解细胞周围底物的酶。它们已从牙本质、成牙本质细胞、牙髓和根尖周组织中分离出来。它们在牙本质基质形成、调控龋病进展和继发性牙本质形成中发挥重要作用。早期的微生物蛋白水解酶被认为负责牙本质有机基质的降解，但最近积累的大量证据表明，MMPs在这一过程中发挥了重要作用。在正常的组织建模、发育过程中的分化、调节细胞行为、维持动态平衡以及许多细胞外的病理条件中，MMPs往往都是同样重要的参与者。成牙本质细胞在生理和病理条件下都能分泌一些必需的基质金属蛋白酶。基质金属蛋白酶似乎也参与了可逆性和不可逆性牙髓炎的过程。虽然它们在成人组织中的表达和活性往往较低，但在任何破坏性的病理过程开始时，它们的产量都会迅速增加。在根尖周部发炎时，它们似乎也有显著的存在。我们看了各种因素和证据，指出MMPs在龋病、牙髓和根尖周炎的发展过程中所起的作用。
Matrix metalloproteinases (MMPs) are a group of more than 25 secreted and membrane bound enzymes that represent class of enzymes responsible for degradation of pericellular substrates. They have been isolated from dentine, odontoblasts, pulp and periapical tissue. They play an important role in dentine matrix formation, modulating caries progression and secondary dentine formation. Earlier microbial proteolytic enzymes were believed to be responsible for degradation of dentine organic matrix, but lately the accumulated body of evidence suggests that MMPs have an important role in the process. During normal tissue modelling, differentiation during development, in modulating the cell behaviour, maintaining homeostasis and in numerous extracellular pathologic conditions, MMPs tends to be an equally important participant. Odontoblasts secrete some of the essential MMPs for both physiologic and pathologic conditions. MMPs also appear to be a participant in the process of reversible and irreversible pulpitis. Although they tend to have low expression and activity in adult tissues but at the onset of any destructive pathologic process, their production shoots up. They appear to have a significant presence during times of inflammation in the periapical region as well. We take a look at the various factors and evidence pointing towards the role of MMPs in the progression of caries, pulpal and periapical inflammation.