Rapidly disassembling nanomicelles with disulfide-linked PEG shells for glutathione-mediated intracellular drug delivery
Rapidly disassembling nanomicelles with disulfide-linked PEG shells for glutathione-mediated intracellular drug delivery
复制标题
快速拆卸具有二硫键连接的 PEG 外壳的纳米胶束，用于谷胱甘肽介导的细胞内药物递送
DOI：
10.1039/c0cc04983b
复制
发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Shi, Dong-Lu
中科院分区：
文献类型：
--
作者：
Wen, Hui-Yun;Dong, Hai-Qing;Shi, Dong-Lu
报道了新型纳米胶束的合成和生物学功效，该纳米胶束在肿瘤相关的谷胱甘肽（GSH）水平下在细胞内快速分解并释放其封装的有效负载。独特的设计包括 PEG 可脱落的外壳和具有氧化还原敏感二硫键的聚（e-苄氧基羰基-L-赖氨酸）核心。
The synthesis and biological efficacy of novel nanomicelles that rapidly disassemble and release their encapsulated payload intracellularly under tumor-relevant glutathione (GSH) levels are reported. The unique design includes a PEG-sheddable shell and poly(e-benzyloxycarbonyl-L-lysine) core with a redox-sensitive disulfide linkage.