Three pairs of diastereoisomeric flavanone glycosides from Viscum articulatum
Three pairs of diastereoisomeric flavanone glycosides from Viscum articulatum
复制标题
槲寄生中的三对非对映异构黄烷酮苷
DOI：
10.1016/j.fitote.2015.03.009
复制
发表时间：
2015-04-01
期刊：
影响因子：
3.4
通讯作者：
Ren, Dongmei
中科院分区：
文献类型：
--
作者：
Li, Haizhen;Hou, Zhun;Ren, Dongmei
对槲寄生（Viscum articulatum）的叶和茎进行植物化学检测，分离出三对新的黄烷酮糖苷，2 R/2S-visarticulide A-C（1a/1b-3a/3b），以及八个已知化合物（7-14）。通过大量的光谱数据分析确定了它们的结构。通过HPLC在手性相上分离非对映异构体，并通过圆二色谱（CD）光谱确定C-2处的绝对构型。测试化合物1-3对EA.hy926细胞的H2 O2诱导的细胞毒性的保护作用。结果表明，化合物1-3在测试浓度下暴露于H2 O2后改善了EA.hy926细胞的存活。(C)2015年由Elsevier B. V.出版
Phytochemical examination of the leaves and stems of Viscum articulatum resulted in the isolation of three pairs of new flavanone glycosides, 2R/2S-viscarticulide A-C (1a/1b-3a/3b), together with eight known compounds (7-14). Their structures were established by extensive spectroscopic data analyses. The diastereoisomers were separated by HPLC on a chiral phase and the absolute configuration at C-2 was determined by circular dichroism (CD) spectra. The protective effects of compounds 1-3 against H2O2-induced cytotoxicity with EA.hy926 cells were tested. The results showed that compounds 1-3 improved the survival of EA.hy926 cells after H2O2 exposure at the tested concentrations. (C) 2015 Published by Elsevier B.V.