IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer.
IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer.
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DOI：
10.1080/2162402x.2015.1027473
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发表时间：
2015-09
期刊：
影响因子：
7.2
通讯作者：
Brunner TB
中科院分区：
文献类型：
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作者：
Lunardi S;Lim SY;Muschel RJ;Brunner TB
胰腺星状细胞（PSCs）是胰腺导管腺癌（PDAC）的关键组成部分。我们最近证明，在胰腺癌细胞（PCCs）存在时，PSCs高度表达IP-10/CXCL10，其表达与调节性T细胞（Tregs）的浸润和生存率低相关。可见，胰腺癌基质细胞通过表达IP-10促进免疫抑制和肿瘤进展。
Pancreatic stellate cells (PSCs) are key components of pancreatic ductal adenocarcinoma (PDAC). We recently demonstrated that IP-10/CXCL10 is highly expressed by PSCs in the presence of pancreatic cancer cells (PCCs) and its expression correlates with infiltration by regulatory T cells (Tregs) and poor survival. Thus, stromal cells in pancreatic cancer can promote immunosuppression and tumor progression, through the expression of IP-10.