Regulation of Pancreatic Beta Cell Stimulus-Secretion Coupling by microRNAs.
Regulation of Pancreatic Beta Cell Stimulus-Secretion Coupling by microRNAs.
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DOI：
10.3390/genes5041018
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发表时间：
2014-11-06
期刊：
影响因子：
3.5
通讯作者：
Eliasson L
中科院分区：
文献类型：
--
作者：
Esguerra JL;Mollet IG;Salunkhe VA;Wendt A;Eliasson L
餐后血糖升高会被胰腺β细胞释放的降血糖激素胰岛素抵消。分子事件的级联包括葡萄糖的初始感知和转运到β细胞中，最终以胰岛素大致密核心颗粒（LDCV）的胞吐作用而告终，称为“刺激-分泌偶联”。任何相关过程的损伤都会导致胰岛素释放不足，这会导致2型糖尿病（T2 D）的发展。当暴露于疾病的环境触发因素时，β细胞的命运取决于通过调节基因表达来适应新情况的可能性。microRNAs（miRNAs）作为转录后调控因子，是β细胞可塑性和适应性的重要调节因子。在这里，我们把重点放在理解miRNAs的转录调控的重要性，以及miRNAs是如何参与刺激分泌耦合，特别是那些影响胰岛素分泌的后期阶段。我们认为，有效的β细胞适应需要miRNA本身的转录调节和miRNA依赖性基因调节之间的最佳平衡。对β细胞转录网络（包括非编码RNA，如miRNA）的了解增加，对于鉴定治疗T2 D的新靶点至关重要。
Increased blood glucose after a meal is countered by the subsequent increased release of the hypoglycemic hormone insulin from the pancreatic beta cells. The cascade of molecular events encompassing the initial sensing and transport of glucose into the beta cell, culminating with the exocytosis of the insulin large dense core granules (LDCVs) is termed “stimulus-secretion coupling.” Impairment in any of the relevant processes leads to insufficient insulin release, which contributes to the development of type 2 diabetes (T2D). The fate of the beta cell, when exposed to environmental triggers of the disease, is determined by the possibility to adapt to the new situation by regulation of gene expression. As established factors of post-transcriptional regulation, microRNAs (miRNAs) are well-recognized mediators of beta cell plasticity and adaptation. Here, we put focus on the importance of comprehending the transcriptional regulation of miRNAs, and how miRNAs are implicated in stimulus-secretion coupling, specifically those influencing the late stages of insulin secretion. We suggest that efficient beta cell adaptation requires an optimal balance between transcriptional regulation of miRNAs themselves, and miRNA-dependent gene regulation. The increased knowledge of the beta cell transcriptional network inclusive of non-coding RNAs such as miRNAs is essential in identifying novel targets for the treatment of T2D.
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影响因子：
3.7
作者：
Esguerra JL;Eliasson L
通讯作者：
Eliasson L
DOI：
10.1016/j.bbrc.2012.08.082
发表时间：
2012-09-21
影响因子：
3.1
作者：
Bagge, Annika;Clausen, Trine R.;Dalgaard, Louise T.
通讯作者：
Dalgaard, Louise T.
影响因子：
16.6
作者：
Gandasi, Nikhil R.;Barg, Sebastian
通讯作者：
Barg, Sebastian
影响因子：
4.5
作者：
Dayeh T;Volkov P;Salö S;Hall E;Nilsson E;Olsson AH;Kirkpatrick CL;Wollheim CB;Eliasson L;Rönn T;Bacos K;Ling C
通讯作者：
Ling C
影响因子：
7.7
作者：
El Ouaamari A;Baroukh N;Martens GA;Lebrun P;Pipeleers D;van Obberghen E
通讯作者：
van Obberghen E