Unintended Compositional Changes in Genetically Modified (GM) Crops: 20 Years of Research
Unintended Compositional Changes in Genetically Modified (GM) Crops: 20 Years of Research
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DOI：
10.1021/jf400135r
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发表时间：
2013-12-04
影响因子：
6.1
通讯作者：
Herman, Rod A.
中科院分区：
文献类型：
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作者：
Herman, Rod A.
20年来，转基因作物和非转基因对照之间的成分等价性一直是人类健康安全评估的基本组成部分。在此期间，人们积累了大量关于转基因过程和传统育种方法所伴随的成分变化的信息；此外，这些变化背后的遗传机制也得到了阐明。二十年后，科学家们被鼓励客观地评估这一文献，并确定是否仍然存在足够的科学不确定性，以继续这些研究的一般要求，以支持转基因作物的安全评估。由此得出的结论是，在大量文献的基础上，可能由基因改造引起的可疑的意外成分效应尚未成为现实。因此，转基因作物特有的成分等效性研究可能不再基于科学上的不确定性而被证明是合理的。
The compositional equivalency between genetically modified (GM) crops and nontransgenic comparators has been a fundamental component of human health safety assessment for 20 years. During this time, a large amount of information has been amassed on the compositional changes that accompany both the transgenesis process and traditional breeding methods; additionally, the genetic mechanisms behind these changes have been elucidated. After two decades, scientists are encouraged to objectively assess this body of literature and determine if sufficient scientific uncertainty still exists to continue the general requirement for these studies to support the safety assessment of transgenic crops. It is concluded that suspect unintended compositional effects that could be caused by genetic modification have not materialized on the basis of this substantial literature. Hence, compositional equivalence studies uniquely required for GM crops may no longer be justified on the basis of scientific uncertainty.