Clinical Epidemiology of Eosinophilic Pustular Folliculitis: Results from a Nationwide Survey in Japan
Clinical Epidemiology of Eosinophilic Pustular Folliculitis: Results from a Nationwide Survey in Japan
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DOI：
10.1159/000368774
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发表时间：
2015-01-01
期刊：
影响因子：
3.4
通讯作者：
Miyachi, Yoshiki
中科院分区：
文献类型：
--
作者：
Yamamoto, Yosuke;Nomura, Takashi;Miyachi, Yoshiki
背景资料：没有流行病学研究检查嗜酸性脓疱性毛囊炎（EPF）患者的临床特征，包括药物使用。目的：描述EPF的临床特征，并探讨影响口服消炎痛治疗EPF疗效的相关因素。研究方法：对日本67个主要教学机构的皮肤科就诊的EPF患者进行了一项横断面研究。我们记录了患者的特征，并检查了与口服吲哚美辛有效性相关的因素。结果：共有145例EPF患者入组; 62.8%的患者口服吲哚美辛。多变量分析显示，女性患者更有可能表现出完全响应口服吲哚美辛调整后的混杂因素（调整比例比= 1.93，p = 0.04）。结论：口服吲哚美辛已被接受作为EPF的一线治疗。我们的研究结果表明，口服吲哚美辛的治疗反应存在性别差异。(C)2014年S. Karger AG，巴塞尔
Background: No epidemiological study has examined the clinical characteristics, including medication use, of patients with eosinophilic pustular folliculitis (EPF). Objective: To describe the clinical characteristics for EPF and to examine the factors associated with the effectiveness of oral indomethacin for EPF. Methods: A cross-sectional study was performed of patients with EPF who visited the dermatology departments of the 67 main teaching facilities in Japan. We documented the patient characteristics and examined factors associated with the effectiveness of oral indomethacin. Results: A total of 145 patients with EPF were enrolled; 62.8% were prescribed oral indomethacin. A multivariable analysis revealed that female patients were more likely to exhibit complete response to oral indomethacin after adjustment for confounders (adjusted proportion ratio = 1.93, p = 0.04). Conclusion: Oral indomethacin has been accepted as a first-line treatment in EPF. Our results suggest that there is a sex difference in the treatment response to oral indomethacin. (C) 2014 S. Karger AG, Basel