Solid-Phase Colorimetric Sensor Based on Gold Nanoparticle-Loaded Polymer Brushes: Lead Detection as a Case Study
Solid-Phase Colorimetric Sensor Based on Gold Nanoparticle-Loaded Polymer Brushes: Lead Detection as a Case Study
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DOI：
10.1021/ac4001817
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发表时间：
2013-04-16
影响因子：
7.4
通讯作者：
Kim, Dong-Hwan
中科院分区：
文献类型：
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作者：
Ferhan, Abdul Rahim;Guo, Longhua;Kim, Dong-Hwan
我们引入了一种新型固相比色传感器，该传感器通过将未修饰的金纳米颗粒加载到在玻璃上生长的聚（低聚（乙二醇）甲基丙烯酸酯）（PO-EGMA）刷中而轻松制造。我们的工作报告了作为比色传感模块的金属纳米粒子与作为非刚性支架和屏幕的防污聚合物基质的第一个协同组合，以减少非目标分子的干扰。另外，由于纳米复合材料形成在透明基板上，因此可以与溶液相中相同的方式进行固相检测。我们展示了如何使用这种独特的无标记铅检测平台，该平台基于暴露于铅离子时从聚合物刷中释放的金纳米颗粒。实现了 25 pM (S/N = 3) 的超低检测限和 100 pM 至 100 nM (R-2 = 0.987) 的动态范围。此外，该检测对铅的选择性比其他常见重金属离子高出 1000 倍。
We introduce a novel solid-phase colorimetric sensor facilely fabricated by loading unmodified gold nanoparticles into poly(oligo(ethylene glycol)methacrylate) (PO-EGMA) brushes grown on glass. Our work reports the first synergistic combination of metallic nanoparticles acting as a colorimetric sensing module with a nonfouling polymer matrix acting both as a nonrigid scaffold and a screen to reduce interference from nontarget molecules. In addition, as the nanocomposite is formed on a transparent substrate, solid-phase detection can be performed in the same manner as in the solution-phase. We demonstrate the use of this unique platform for label-free lead detection based on the release of gold nanoparticles from the polymer brush upon exposure to lead ions. An ultralow limit-of-detection of 25 pM (S/N = 3) and a dynamic range of 100 pM to 100 nM (R-2 = 0.987) are achieved. Furthermore, the detection is up to 1000-fold more selective to lead over other common heavy metal ions.