Computed tomography evaluation of paranasal sinuses in asthma: is there a tendency of particular site involvement?
Computed tomography evaluation of paranasal sinuses in asthma: is there a tendency of particular site involvement?
复制标题
哮喘鼻旁窦的计算机断层扫描评估：是否有特定部位受累的趋势？
DOI：
10.2500/aap.2006.27.2892
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发表时间：
2006
影响因子：
2.8
通讯作者：
M. S. Erginel
中科院分区：
文献类型：
--
作者：
B. Adapinar;E. Kurt;M. Kebapçı;M. S. Erginel
尽管确切的机制尚不清楚，但哮喘和慢性鼻窦炎经常相关。计算机断层扫描 (CT) 是记录鼻窦粘膜异常的敏感方式。本研究的目的是评估哮喘中的鼻旁粘膜异常以及是否与哮喘严重程度相关。 155 名哮喘患者和 36 名正常对照受试者接受了冠状窦 CT 评估。哮喘分为轻度、中度或重度。鼻旁窦异常评分针对总鼻窦、总粘膜和个别部位进行评估。与对照组相比，哮喘患者的总粘膜变化平均分（8.45 分与 4.67 分，p < 0.001）和总窦评分（5.50 与 2.69，p < 0.005）显着较高。鼻道和额窦受累情况在各组之间没有统计学差异，但哮喘患者的所有其他个体评分均显着较高。哮喘严重程度的增加存在受累部位的倾向。与血嗜酸性粒细胞计数正常（鼻道疾病除外）的哮喘患者相比，血嗜酸性粒细胞水平高的哮喘患者的平均总粘膜 CT 评分（12.57 分 vs 7.33 分，p < 0.05）和个体部位评分在统计学上更高。总IgE水平与CT评分之间没有显着关系。总粘膜和鼻窦评分与哮喘严重程度显着相关。有鼻窦及部位受累倾向。鼻道受累与哮喘无关。轻度哮喘患者筛窦和口道复合体明显受累，而重度哮喘患者上颌窦、额窦和蝶窦受累明显。
Although the precise mechanism is unclear, asthma and chronic sinusitis are associated frequently. Computed tomography (CT) is a sensitive modality for documenting sinonasal mucosal abnormalities. The aim of this study was to evaluate paranasal mucosal abnormalities in asthma and whether there was a relationship with asthma severity. One hundred fifty-five patients with asthma and 36 normal control subjects were assessed with coronal sinus CT. Asthma was classified as mild, moderate, or severe. Scoring of paranasal sinus abnormalities were assessed for total sinus, total mucosal, and individual sites. The mean scores of total mucosal changes (8.45 points versus 4.67 points, p < 0.001) and total sinus scores (5.50 versus 2.69, p < 0.005) were significantly higher in the asthmatic patients compared with controls. Nasal passage and frontal sinus involvements were not statistically different between groups, but all other individual scores were significantly higher in asthmatic patients. There was an involvement site tendency with respect to increasing severity of asthma. Mean total mucosal CT scores (12.57 points versus 7.33 points, p < 0.05) and individual site scores were statistically higher in asthmatic patients with high blood eosinophil levels compared with those patients with normal blood eosinophil counts except for nasal passage disease. There was no significant relationship between total IgE level and CT scores. Total mucosal and sinus scores were significantly related with asthma severity. There was an involvement tendency of sinuses and sites. Nasal passage involvement was unrelated with asthma. Ethmoidal sinuses and ostiomeatal complexes were involved significantly in patients with mild asthma, whereas maxillary, frontal, and sphenoidal sinuses were involved significantly in patients with severe asthma.