An angiogenic role for the neurokines midkine and pleiotrophin in tumorigenesis.
An angiogenic role for the neurokines midkine and pleiotrophin in tumorigenesis.
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发表时间：
1997-05
期刊：
影响因子：
11.2
通讯作者：
R. Choudhuri;Hua-Tang Zhang;S. Donnini;M. Ziche;R. Bicknell
中科院分区：
文献类型：
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作者：
R. Choudhuri;Hua-Tang Zhang;S. Donnini;M. Ziche;R. Bicknell
最近对膀胱肿瘤的分析表明，神经因子midkine （MK）的表达与患者生存不良有关。为了研究MK和相关的多营养蛋白（PTN）在肿瘤发生中的作用，他们在MCF-7乳腺癌细胞中过表达。表达对体外生长没有影响，但在体内具有生长优势。肿瘤生长增强与血管密度和内皮细胞增殖增加相关，暗示MK和PTN具有血管生成作用。在兔角膜实验中证实了MK和PTN的血管生成活性。因此，我们的数据确定了抗血管生成药物开发的两个新靶点。
Recent analysis of bladder tumors has correlated expression of the neurokine midkine (MK) with poor patient survival. To examine a role for MK and the related pleiotrophin (PTN) in tumorigenesis, they were overexpressed in MCF-7 breast carcinoma cells. Expression had no effect on in vitro growth but conferred a growth advantage in vivo. Enhanced tumor growth correlated with increased vascular density and endothelial proliferation, implicating an angiogenic role for MK and PTN. Angiogenic activity of MK and PTN was confirmed in the rabbit corneal assay. Our data therefore identify two novel targets for antiangiogenic drug development.