A SODIUM-POTASSIUM SWITCH IN THE FORMATION OF 4-STRANDED G4-DNA
A SODIUM-POTASSIUM SWITCH IN THE FORMATION OF 4-STRANDED G4-DNA
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DOI：
10.1038/344410a0
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发表时间：
1990-03-29
期刊：
影响因子：
64.8
通讯作者：
GILBERT, W
中科院分区：
文献类型：
--
作者：
SEN, D;GILBERT, W
Single-stranded complex guanine-rich DNA sequences from chromosomal telomeres and else-where can associate to form stable parallel four-stranded structures termed G4-DNA by a process that is anomalously dependent on the particular alkali metal cation that is present. The anomaly, which is not found in the formation of G4-DNA by oligonucleotides containing short, single runs of three or more guanines, is caused by potassium cations excessively stabilizing fold-back intermedi-ate structures, or pathway by-products.
