Adiponectin in relation to insulin sensitivity and insulin secretion in the development of type 2 diabetes: a prospective study in 64-year-old women
Adiponectin in relation to insulin sensitivity and insulin secretion in the development of type 2 diabetes: a prospective study in 64-year-old women
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DOI：
10.1111/j.1365-2796.2010.02336.x
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发表时间：
2011-06-01
影响因子：
11.1
通讯作者：
Behre, C. J.
中科院分区：
文献类型：
--
作者：
Fagerberg, B.;Kellis, D.;Behre, C. J.
Fagerberg B，Kellis D，Bergstrom G，Behre CJ（瑞典哥德堡，哥德堡大学Sahlliska学院）.脂联素与2型糖尿病胰岛素敏感性和胰岛素分泌的关系：一项在64岁女性中进行的前瞻性研究J Intern Med 2011; 269：636- 643.目的：研究血清脂联素水平如何预测2型糖尿病的发病率，从不同的糖尿病前期状态，在5.5年的随访中，与胰岛素敏感性和β细胞功能有关。方法：在一个基于人群的64岁白人妇女队列中，我们评估了葡萄糖耐量，胰岛素敏感性作为稳态模型评估，胰岛素分泌作为急性胰岛素反应、生活方式因素以及脂联素和高敏C反应蛋白的血清浓度。随访5.5年后，对167例糖耐量正常（NGT）和174例糖耐量受损（IGT）的女性进行复查，并评估糖尿病的发病率。基线时血清脂联素水平低、胰岛素抵抗和胰岛素分泌、吸烟、空腹血糖受损（IFG）和IGT独立预测糖尿病发病率。血清脂联素低于11.54 g L-1与未来2型糖尿病的比值比为3.6（95%置信区间1.4-8.6）相关。基线时，高血清脂联素浓度与高水平胰岛素敏感性和胰岛素分泌呈正相关。糖尿病女性事件有较低的血清脂联素水平在NGT，IFG和IGT组在基线相比，那些谁没有发展成糖尿病在follow-up.Conclusions.Low脂联素浓度与未来的糖尿病独立的胰岛素分泌和敏感性，以及IGT，IFG，吸烟和腹部肥胖。
Fagerberg B, Kellis D, Bergstrom G, Behre CJ (Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden). Adiponectin in relation to insulin sensitivity and insulin secretion in the development of type 2 diabetes: a prospective study in 64-year-old women. J Intern Med 2011; 269: 636-643.Objectives.To examine how serum adiponectin levels predict the incidence of type 2 diabetes, from different prediabetic states, in relation to insulin sensitivity and beta-cell function during 5.5 years of follow-up.Methods.In a population-based cohort of 64-year-old Caucasian women, we assessed glucose tolerance, insulin sensitivity as homeostasis model assessment, insulin secretion as acute insulin response, lifestyle factors and serum concentrations of adiponectin and high-sensitivity C-reactive protein. After 5.5 years of follow-up, 167 women with normal glucose tolerance (NGT) and 174 with impaired glucose tolerance (IGT) at baseline were re-examined and incidence of diabetes was assessed.Results.A total of 69 new cases of diabetes were detected during follow-up. Diabetes incidence was independently predicted by low levels of serum adiponectin, insulin resistance and insulin secretion, cigarette smoking, impaired fasting glucose (IFG) and IGT at baseline. Serum adiponectin below 11.54 g L-1 was associated with an odds ratio of 3.6 (95% confidence interval 1.4-8.6) for future type 2 diabetes. At baseline, a high serum adiponectin concentration correlated positively with high levels of insulin sensitivity and insulin secretion. Women with incident diabetes had lower serum adiponectin levels in the NGT, IFG and IGT groups at baseline compared to those who did not develop diabetes during follow-up.Conclusions.Low adiponectin concentrations were associated with future diabetes independently of insulin secretion and sensitivity, as well as IGT, IFG, smoking and abdominal obesity.