Mass Spectrometry in Biomedical Research
Mass Spectrometry in Biomedical Research
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生物医学研究中的质谱分析
DOI：
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发表时间：
1986
期刊：
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通讯作者：
S. Gaskell
中科院分区：
文献类型：
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作者：
S. Gaskell
这本书提供了一个国家的最先进的报道，在应用质谱（MS）的生物医学研究，已经发生在过去几年的戏剧性扩展。这种扩展是通过电离技术的发展和高质量分析仪器的改进实现的。Gaskall博士汇集了大量杰出和创新的研究人员，他们的主要动机是解决生物医学研究中的问题。主要包括三个方面：a）不稳定和极性化合物的分析，重点是新的样品处理和电离技术，包括对化合物类别的讨论，如白三烯、核酸成分和极性药物代谢物; B）高质量分析，包括对肽、寡核苷酸和寡糖的讨论，并介绍飞行时间和傅里叶变换MS的最新发展;（c）痕量分析，包括使用串联MS和组合的气体和液体色谱法，以非常高的灵敏度检测分析物，如类固醇、异黄酮、肽和药物。这三个部分中的每一个都由Gaskill博士撰写的概述来描述，概述提供了有关电离技术、新的质量分析仪和串联质谱的相关背景材料。
This book provides a stat-of-the-art coverage of the dramatic extension in the application of mass spectrometry (MS) to biomedical research that has taken place in the last few years. This extension has been brought about through both the developments in ionization techniques and through the improved instrumentation for analyses at high mass. Dr Gaskall has brought together a large number of eminent and innovative researchers in MS, whose major motivation is the desire to solve problems in biomedical research. Three general areas are covered: a) Analyses of labile and polar compounds, with emphasis on new sample handling and ionization techniques and including discussion of compound classes such as leukotrienes, nucleic acid constituents and polar drug metabolites; b) Analyses at high mass, including discussions of peptides, oligonucleotides and oligosaccharides and presenting recent developments in time-of-flight and Fourier transform MS; c) Trace analyses, including the use of tandem MS and of combined gas and liquid chromotography for very high sensitivity detection of analytes such as steroids, prostaglandins, peptides and drugs. Each of the three sections are supplemeted by overviews, authored by Dr Gaskill, which provide relevant background material concerning ionization technques, new mass analysers and tandem MS.