Contributions of the anterior forebrain pathway to vocal plasticity
Contributions of the anterior forebrain pathway to vocal plasticity
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DOI：
10.1196/annals.1298.042
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Brainard, MS
中科院分区：
文献类型：
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作者：
Brainard, MS
前前脑通路（AFP）是一个基底神经节-背侧前脑回路，在学习唱歌的鸟类中尤为突出。该回路与歌曲运动通路相互连接，在歌曲产生期间是活跃的，并且包含对鸟自己的歌曲的声音有选择性的神经元，这表明AFP在声乐行为中的重要作用。然而，中断的AFP病变在成年鸟类的学习歌曲的生产几乎没有明显的影响。相比之下，幼鸟的病变阻止了歌曲学习的正常进展。此外，成年人的病变，虽然不中断生产，可以防止经验依赖性可塑性的歌曲。这些数据暗示AFP特别是在歌曲学习和声乐可塑性。本章回顾了一些支持AFP在这些过程中的作用的实验证据，并讨论了潜在的指导和许可功能的AFP在发声可塑性。
The anterior forebrain pathway (AFP) is a basal ganglia-dorsal forebrain circuit that is prominent specifically in birds that learn to sing. This circuit is interconnected with the song motor pathway, is active during song production, and contains neurons that are selective for the sound of the bird's own song, suggesting an important role for the AFP in vocal behavior. However, interruption of the AFP by lesions in adult birds has little overt effect on the production of learned song. In contrast, lesions in juvenile birds prevent the normal progression of song learning. Moreover, lesions in adults, while not disrupting production, can prevent experience-dependent plasticity of song. Such data implicate the AFP specifically in song learning and vocal plasticity. This chapter reviews some of the experimental evidence supporting a role for the AFP in these processes and discusses potential instructive and permissive functions of the AFP in vocal plasticity.