The repertoire of T cells shaped by a single MHC/peptide ligand
The repertoire of T cells shaped by a single MHC/peptide ligand
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DOI：
10.1016/s0092-8674(00)81028-4
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发表时间：
1996-02-23
期刊：
影响因子：
64.5
通讯作者：
Marrack, P
中科院分区：
文献类型：
--
作者：
Ignatowicz, L;Kappler, J;Marrack, P
虽然胸腺会产生许多未成熟的胸腺细胞，但这些细胞很少成熟。正向选择一直被认为限制胸腺细胞的发育。然而，在表达单一MHC/肽组合的胸腺中，令人惊讶的是大量胸腺细胞被选择成熟。其中许多与选择的MHC反应，并与其他自体多肽结合。因此，成熟的胸腺细胞的数量受到这样一个事实的限制，即积极选择的细胞死亡，因为它们与与自身多肽结合的MHC反应太好，而这些多肽与参与正选择的细胞不同。在胸腺中成熟的表达单一MHC/肽配体的T细胞经常与外来MHC反应，这表明α-β受体可能比之前认为的更偏向于与MHC反应。
Although the thymus produces many immature thymocytes, few of these cells mature. Positive selection has been thought to limit thymocyte development. In thymuses expressing a single MHC/peptide combination, however, surprisingly large numbers of thymocytes are selected to mature. Many of these react with the selecting MHC, bound to other self-peptides. Therefore, the number of thymocytes that mature is limited by the fact that positively selected cells die because they react too well with MHC bound to self-peptides that are not identical to those involved in positive selection. T cells that mature in thymuses expressing a single MHC/peptide ligand react frequently with foreign MHC, suggesting that the repertoire of alpha beta receptors may be more biased toward reaction with MHC than was previously thought.