Persistence of Long-Term Memory Storage: New Insights into its Molecular Signatures in the Hippocampus and Related Structures
Persistence of Long-Term Memory Storage: New Insights into its Molecular Signatures in the Hippocampus and Related Structures
复制标题
DOI：
10.1007/s12640-010-9155-5
复制
发表时间：
2010-11-01
影响因子：
3.7
通讯作者：
Medina, Jorge H.
中科院分区：
文献类型：
--
作者：
Bekinschtein, Pedro;Katche, Cynthia;Medina, Jorge H.
虽然我们对长期记忆（LTM）的巩固有很多了解，但在LTM中，“长”是随着时间的推移而持续的唯一特征。然而，直到最近，记忆持久性背后的分子机制从未得到过适当的研究。在大鼠中，蛋白质翻译抑制剂茴香霉素在抑制性回避（IA）训练后12小时注射到背侧海马中时损害记忆持久性，而不影响记忆形成。在这里，我们还显示了IA训练后18-24小时左右海马c-Fos，Homer 1a，Akt，CamKII alpha和ERK 2水平的学习诱导变化。因此，记忆持续性与海马体中可塑性相关蛋白质合成的晚期阶段有关。
Although much is known about long-term memory (LTM) consolidation, what puts the "long" in LTM is the exclusive feature of persisting over time. However, until recently the molecular mechanisms underneath memory persistence had never been properly studied. In rats, the protein translation inhibitor anisomycin impaired memory persistence when injected into the dorsal hippocampus 12 h after inhibitory avoidance (IA) training without affecting memory formation. Here, we also show learning-induced changes in hippocampal c-Fos, Homer 1a, Akt, CamKII alpha, and ERK2 levels around 18-24 h after IA training. Thus, memory persistence is associated with a late phase of plasticity-related protein synthesis in the hippocampus.