Glucagon-like peptide-1 in diabetes care: Can glycaemic control be achieved without nausea and vomiting?
Glucagon-like peptide-1 in diabetes care: Can glycaemic control be achieved without nausea and vomiting?
复制标题
胰高血糖素样肽-1在糖尿病护理中的应用：在不发生恶心和呕吐的情况下能否实现血糖控制？
DOI：
10.1111/bph.15647
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发表时间：
2022-03
影响因子：
7.3
通讯作者：
De Jonghe BC
中科院分区：
文献类型：
--
作者：
Borner T;Tinsley IC;Doyle RP;Hayes MR;De Jonghe BC
Introduced less than two decades ago, glucagon-like peptide-1 receptor agonists rapidly reshaped the field of Type 2 diabetes mellitus (T2DM) care by providing glycaemic control in tandem with weight loss. However, FDA-approved GLP-1 receptor agonists are often accompanied by nausea and emesis and, in some lean T2DM patients, by undesired anorexia. Importantly, the hypophagic and emetic effects of GLP-1 receptor agonists are caused by activation of central GLP-1 receptors. This review summarizes two different approaches to mitigate the incidence and severity of nausea and emesis related to GLP-1 receptor agonists: conjugation with vitamin B12, or related corrin ring-containing compounds (‘corrination’), and development of dual agonists of GLP-1 receptors with glucose-dependent insulinotropic polypeptide (GIP). Such approaches could lead to the generation of GLP-1 receptor agonists with improved therapeutic efficacy, thus decreasing treatment attrition, increasing patient compliance and extending treatment to a broader population of T2DM patients. The data reviewed show that it is possible to pharmacologically separate the emetic effects of GLP-1 receptor agonists from their glucoregulatory action.
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影响因子：
16.2
作者：
Buse, John B.;Wexler, Deborah J.;Davies, Melanie J.
通讯作者：
Davies, Melanie J.
影响因子：
2.1
作者：
Ambati, S.;Duan, J.;Baile, C. A.
通讯作者：
Baile, C. A.
DOI：
10.1152/ajpregu.00424.2010
发表时间：
2011-10-01
影响因子：
2.8
作者：
Baraboi, Elena-Dana;St-Pierre, David H.;Richard, Denis
通讯作者：
Richard, Denis
影响因子：
8.8
作者：
Borner, Tito;Workinger, Jayme L.;Doyle, Robert P.
通讯作者：
Doyle, Robert P.
影响因子：
5.3
作者：
Alhadeff, Amber L.;Holland, Ruby A.;De Jonghe, Bart C.
通讯作者：
De Jonghe, Bart C.