DECLINING SEMEN QUALITY AND INCREASING INCIDENCE OF TESTICULAR CANCER - IS THERE A COMMON-CAUSE
DECLINING SEMEN QUALITY AND INCREASING INCIDENCE OF TESTICULAR CANCER - IS THERE A COMMON-CAUSE
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DOI：
10.2307/3432523
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发表时间：
1995-10-01
影响因子：
10.4
通讯作者：
SKAKKEBAEK, NE
中科院分区：
文献类型：
--
作者：
CARLSEN, E;GIWERCMAN, A;SKAKKEBAEK, NE
男性生殖在科学和医学实践中很少受到关注。然而，最近一项关于精液质量的荟萃分析却被多次引用，该分析明确指出过去 50 年来精液质量有所下降。最近的三份报告发现，过去 20 年来候选精液捐赠者的精液质量有所下降。精液质量下降的证据并不是人类睾丸面临风险的唯一指标。在过去的 50 年里，睾丸癌也变得更加常见。这是一种年轻男性的疾病，与其他睾丸异常的高发生率有关，包括睾丸未降和精液质量差。此外，据报道，尿道下裂和睾丸未降的发病率在普通人群中呈上升趋势。我们认为，应该根据男性其他生殖疾病的这些趋势来看待精液质量下降的证据。然而，病因尚不清楚。讨论了最近的一个假设，该假设将男性生殖系统的健康趋势与环境中的异雌激素联系起来。
Male reproduction has been given little attention in science and in medical practice. However, a recent metaanalysis on semen quality, which clearly pointed to a decrease over the past 50 years, has been repeatedly quoted. Three recent reports have found that semen quality has declined among candidate semen donors during the past 20 years. The evidence of decline in the quality of semen is not the only indicator that the human testis is at risk. During the past 50 years, cancer of the testis has also become more common. This is a disorder of young men, and it is associated with a high rate of the other abnormalities of the testis including undescended testis and poor semen quality. Furthermore, the incidence of both hypospadias and undescended testis has been reported to be rising in the general population. We believe that the evidence of declining semen quality should be seen in the light of these trends in other reproductive disorders of men. However, the etiology is unknown. A recent hypothesis that links the trends in the health of the male reproductive system to xenoestrogens in the environment is discussed.