Synthesis of a C4-epi-C1-C6 fragment of FR901464 using a novel bromolactolization
Synthesis of a C4-epi-C1-C6 fragment of FR901464 using a novel bromolactolization
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DOI：
10.1021/ol049160w
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发表时间：
2004-10-14
期刊：
影响因子：
5.2
通讯作者：
Koide, K
中科院分区：
文献类型：
--
作者：
Albert, BJ;Koide, K
本文报道抗肿瘤药物FR 901464的C_4-epi-C_1-C_6片段的合成。本研究中制备的高级中间体含有FR 901464的C1-C6部分中发现的三个正确立体中心中的两个。为了制备该中间体，我们已经开发了一种高度非对映选择性的溴代内酯化的δ-烯基酮。
A synthesis of a C4-epi-C1-C6 fragment of the antitumor agent FR901464 is reported. The advanced intermediate prepared in this study contains two of the three correct stereocenters found in the C1-C6 moiety of FR901464. For the preparation of this intermediate, we have developed a highly diastereoselective bromolactolization of a delta-alkenyl ketone.