C4b-binding protein (C4BP) activates B cells through the CD40 receptor
C4b-binding protein (C4BP) activates B cells through the CD40 receptor
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DOI：
10.1016/s1074-7613(03)00149-3
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发表时间：
2003-06-01
期刊：
影响因子：
32.4
通讯作者：
Geha, RS
中科院分区：
文献类型：
--
作者：
Brodeur, SR;Angelini, F;Geha, RS
我们证明，A。人C4 B结合蛋白（C4 BP）的链在与CD 40配体所用的位点不同的位点直接结合人B细胞上的CD 40。C4 BP诱导正常B细胞增殖、上调CD 54和CD 86表达以及IL 4依赖性IgE同种型转换，但在CD 40或IKK γ/NEMO缺陷患者的B细胞中不诱导。此外，C4 BP与B细胞共定位于人扁桃体的生发中心。这些观察结果表明，C4 BP是一个活化配体的CD 40和建立一个新的接口之间的补体和B细胞活化。
We demonstrate that the a. chain of human C4b binding protein (C4BP) binds directly to CD40 on human B cells at a site that differs from that used by CD40 ligand. C4BP induces proliferation, upregulation of CD54 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells from patients with CD40 or IKKgamma/NEMO deficiencies. Furthermore, C4BP colocalized with B cells in the germinal centers of human tonsils. These observations suggest that C4BP is an activating ligand for CD40 and establish a novel interface between complement and B cell activation.