The Effect of Acute and Chronic Ethanol Administration on Prolactin Secretion in Male Rats
The Effect of Acute and Chronic Ethanol Administration on Prolactin Secretion in Male Rats
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急、慢性乙醇给药对雄性大鼠催乳素分泌的影响
DOI：
10.1002/j.1939-4640.1982.tb00697.x
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发表时间：
1982
影响因子：
--
通讯作者：
And Luciano Debeljuk
中科院分区：
文献类型：
--
作者：
A. Seilicovich;V. Rettori;O. Koch;B. Duvilanski;M. C. Dı́az;And Luciano Debeljuk
研究了基础条件下和舒必利给药后急性和慢性给药乙醇对雄性大鼠催乳素分泌的影响。还检查了乙醇对下丘脑谷氨酸脱羧酶（GAD）活性的影响。急性给予乙醇显着增加血清催乳素水平。服用舒必利后这种增加持续存在。相反，长期服用乙醇并没有显着改变血清催乳素水平。然而，长期用乙醇治疗的大鼠注射舒必利后催乳素水平的升高明显低于对照动物。急性或长期服用乙醇不会显着改变催乳素的垂体浓度。与对照大鼠的效果相比，舒必利未能降低经乙醇急性处理的大鼠垂体中催乳素的浓度。急性乙醇治疗显着降低下丘脑 GAD 活性，而长期乙醇治疗则导致下丘脑 GAD 活性增加。这些结果表明乙醇可以改变下丘脑催乳素的分泌和 GABA 的合成。
The effect of acute and chronic administration of ethanol on prolactin secretion in male rats was investigated under basal conditions and after the administration of sulpiride. The effect of ethanol on the activity of glutamic acid decarboxylase (GAD) in the hypothalamus was also examined. Acute administration of ethanol significantly increased serum prolactin levels. This increase persisted after sulpiride administration. In contrast, chronic administration of ethanol did not significantly modify serum prolactin levels. However, the elevation of prolactin levels in response to the injection of sulpiride was significantly lower in rats chronically treated with ethanol than in control animals. Pituitary concentration of prolactin was not significantly modified by acute or chronic administration of ethanol. Sulpiride administration failed to reduce the concentration of prolactin in the pituitary of rats acutely treated with ethanol, in contrast to its effect in control rats. Acute administration of ethanol significantly decreased hypothalamic GAD activity, while chronic ethanol treatment caused an increase in GAD activity in the hypothalamus. These results indicate that ethanol can alter prolactin secretion and the synthesis of GABA in the hypothalamus.