Impact of consuming a milk drink containing a probiotic on mood and cognition
Impact of consuming a milk drink containing a probiotic on mood and cognition
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DOI：
10.1038/sj.ejcn.1602546
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发表时间：
2007-03-01
影响因子：
4.7
通讯作者：
Brown, A.
中科院分区：
文献类型：
--
作者：
Benton, D.;Williams, C.;Brown, A.
目的：检查饮用含有益生菌的牛奶饮料或安慰剂对情绪和记忆的影响，因为之前发现情绪不佳与便秘频率相关。设计：一项随机分配受试者的双盲安慰剂对照试验。背景：除了 3 次去实验室外，受试者在社区过着正常的生活。受试者：132 名健康普通人群，平均年龄 61.8 岁，自愿响应当地媒体覆盖范围。一百二十四人完成了试验。干预：在三周的时间内，每天饮用含益生菌的牛奶饮料或安慰剂。在基线以及食用 10 天和 20 天后测量情绪和认知能力。结果：在基线时，那些自称便秘频率较低的人更加头脑清醒、自信和兴高采烈。尽管服用益生菌通常不会改变情绪，但这似乎反映了该样本中总体良好的情绪。当考虑到基线时处于抑郁/兴高采烈维度底部三分之一的人时，他们选择性地做出反应，在服用益生菌后报告自己快乐而不是抑郁。然而，干预措施并没有影响报告的排便频率，这可能反映了最初的便秘发生率较低。一个意外且可能是偶然的发现是，食用益生菌会导致两项记忆力测试的表现稍差。结论：食用含益生菌的酸奶可以改善那些最初情绪不佳的人的情绪。然而，情绪的改善与排便频率的增加无关。
Objective: The impact on mood and memory of consuming a probiotic containing milk drink, or a placebo, was examined as, previously, a poor mood has been found to correlate with the frequency of constipation.Design: A double-blind placebo-controlled trial with random allocation of subjects.Setting: Subjects went about their normal life in the community apart from three visits to the laboratory.Subjects: One hundred and thirty-two healthy members of general population, mean age 61.8 years, volunteered in response to local media coverage. One hundred and twenty-four finished the trial.Intervention: For a 3-week period, either a probiotic containing milk drink, or a placebo, were consumed daily. Mood and cognition were measured at baseline, and after 10 and 20 days of consumption.Results: At baseline those who reported themselves to be less frequently constipated were more clearheaded, confident and elated. Although the taking of the probiotic did not generally change the mood, this appeared to be a reflection of the generally good mood in this sample. When those in the bottom third of the depressed/elated dimension at baseline were considered, they selectively responded by reporting themselves as happy rather than depressed after taking the probiotic. The intervention did not, however, influence the reported frequency of defaecation, probably a reflection of the initially low incidence of constipation. An unexpected and possibly chance finding was that the consumption of probiotics resulted in a slightly-poorer performance on two measures of memory.Conclusions: The consumption of a probiotic-containing yoghurt improved the mood of those whose mood was initially poor. This improvement in mood was not, however, associated with an increased frequency of defaecation.