Longitudinal 3-D Visualization of Microvascular Disruption and Perfusion Changes in Mice During the Evolution of Glioblastoma Using Super-Resolution Ultrasound.
Longitudinal 3-D Visualization of Microvascular Disruption and Perfusion Changes in Mice During the Evolution of Glioblastoma Using Super-Resolution Ultrasound.
复制标题
使用超分辨率超声对胶质母细胞瘤进化过程中小鼠的微血管破坏和灌注变化进行纵向 3D 可视化。
DOI：
10.1109/tuffc.2023.3320034
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Dayton,PaulA
中科院分区：
文献类型：
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作者：
McCall,JacobR;DeRuiter,Ryan;Ross,Mark;Santibanez,Francisco;Hingtgen,ShawnD;Pinton,GianmarcoF;Dayton,PaulA
胶质母细胞瘤是一种侵袭性的脑癌，预后非常差，只有不到6%的患者在确诊后存活超过五年。对于许多患者来说，这种疾病的预后可以通过早期发现而得到改善。这可以为临床医生提供所需的信息，以便及早采取治疗行动。在这项工作中，我们提出了一种非侵入性的全体积超声成像方法来评估小鼠胶质母细胞瘤演变过程中微血管的变化。使用体积超声定位显微镜(ULM)观察在三周的过程中功能性血管的外观有统计学意义的减少。我们还证明了肿瘤周围血管血流量减少的证据。以82.5%的符合率获得高质量的血管图像，我们证明了容积ULM作为神经疾病微血管表征的纵向方法的可能性。
Glioblastoma is an aggressive brain cancer with a very poor prognosis in which less than 6% of patients survive more than five-year post-diagnosis. The outcome of this disease for many patients may be improved by early detection. This could provide clinicians with the information needed to take early action for treatment. In this work, we present the utilization of a non-invasive, fully volumetric ultrasonic imaging method to assess microvascular change during the evolution of glioblastoma in mice. Volumetric ultrasound localization microscopy (ULM) was used to observe statistically significant () reduction in the appearance of functional vasculature over the course of three weeks. We also demonstrate evidence suggesting the reduction of vascular flow for vessels peripheral to the tumor. With an 82.5% consistency rate in acquiring high-quality vascular images, we demonstrate the possibility of volumetric ULM as a longitudinal method for microvascular characterization of neurological disease.