IL-1β, IL-17A and combined phototherapy predicts higher while previous systemic biologic treatment predicts lower treatment response to etanercept in psoriasis patients
IL-1β, IL-17A and combined phototherapy predicts higher while previous systemic biologic treatment predicts lower treatment response to etanercept in psoriasis patients
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DOI：
10.1007/s10787-018-0530-9
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发表时间：
2019-02-01
影响因子：
5.8
通讯作者：
Cao, Jingjing
中科院分区：
文献类型：
--
作者：
Liu, Yufang;Qin, Guifang;Cao, Jingjing
背景本研究旨在探讨依那西普（etanercept，ETN）治疗银屑病患者循环中炎性细胞因子水平与疗效的关系。于治疗前及治疗后6个月（M6）采集血清，采用酶联免疫吸附法检测9种炎性细胞因子的表达。分别于治疗前（M0）、治疗后1个月（M1）、3个月（M3）和治疗后6个月（M6）进行银屑病面积和严重程度指数（PASI）评分，并计算相应的PASI 75/90应答率。而IL-10水平在ETN治疗后M6较基线升高。在M6时，ETN的PASI 75/90应答率分别为69.1%和38.1%。与PASI 75无应答患者相比，PASI 75应答患者的IL-1和IL-17 A水平升高，而与PASI 90无应答患者相比，PASI 90应答患者的IL-17 A水平也升高。多因素Logistic回归分析显示，IL-1、IL-17 A和研究期间的联合光疗预测更高，而先前的全身生物治疗独立地预测更低的PASI 75对ETN的反应。此外，IL-17 A独立预测更高的PASI 90响应ETN，以及.ConclusionsIL-1，IL-17 A，并结合光疗预测更高，而以前的全身生物治疗预测较低的治疗反应ETN独立银屑病患者。
BackgroundThis study aimed to explore the correlation of circulating inflammatory cytokines' levels with treatment response to etanercept (ETN) treatment in psoriasis patients.Methods97 moderate-to-severe plaque-psoriasis patients were continuously recruited in this prospective cohort study, and all patients received ETN treatment. Serum samples were collected before and at 6months (M6) after treatment, and nine inflammatory cytokines expressions were detected by enzyme-linked immuno sorbent assay. Psoriasis Area and Severity Index (PASI) score was evaluated at baseline (M0), 1month (M1), 3months (M3) and M6 after treatment, and the corresponding PASI 75/90 responses' rates were calculated.ResultsTumor necrosis factor-alpha (TNF-), interleukin (IL)-1, IL-6, IL-12, IL-17A, IL-22, IL-23, and IL-32 levels were reduced, while IL-10 level was elevated at M6 after ETN treatment compared to baseline. PASI 75/90 responses' rates to ETN were 69.1 and 38.1% at M6, respectively. IL-1 and IL-17A levels were elevated in PASI 75-response patients compared to PASI 75 non-response patients, while IL-17A level was also increased in PASI 90-response patients compared to PASI 90 non-response patients. Multivariate logistic regression revealed that IL-1, IL-17A and combined phototherapy during study predicted higher, while previous systemic biologic treatment predicted lower PASI 75 response to ETN independently. In addition, IL-17A independently predicted higher PASI 90 response to ETN as well.ConclusionsIL-1, IL-17A, and combined phototherapy predicts higher while previous systemic biologic treatment predicts lower treatment response to ETN independently in psoriasis patients.