Enhanced low-frequency oscillatory activity of the subthalamic nucleus in a patient with dystonia
Enhanced low-frequency oscillatory activity of the subthalamic nucleus in a patient with dystonia
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DOI：
10.1002/mds.25078
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发表时间：
2012-07-01
影响因子：
8.6
通讯作者：
Kuehn, Andrea A.
中科院分区：
文献类型：
--
作者：
Neumann, Wolf-Julian;Huebl, Julius;Kuehn, Andrea A.
背景：在1例肌张力障碍患者的丘脑底核(STN)记录到局部场电位，以进一步阐明疾病特异性的基底节振荡活动。方法：记录肌张力障碍患者的STN局部场电位和肌电(EMG)，以估计STN活动与EMG的功率谱和一致性。结果：在我们的患者中，STN功率谱在大约7赫兹处有一个明显的峰值。这一发现与肌张力障碍患者的苍白球活动相似，但与帕金森氏症患者的丘脑下部β活动明显不同。在这位患者中，STN活动和EMG在4至12赫兹频段之间存在显著的一致性。结论：肌张力障碍与皮质-基底节网络中存在的theta范围的病理活动有关。这种活动与帕金森氏症不同，这表明不同的运动障碍可能涉及不同的振荡电路障碍。(C)2012年运动无序社
Background: Local field potentials were recorded from the subthalamic nucleus (STN) in a patient with dystonia to further elucidate disease-specific aspects of basal ganglia oscillatory activity. Methods: STN local field potentials and electromyograms (EMGs) from dystonic muscles were recorded to provide an estimate of the power spectra and coherence between the STN activity and EMG. Results: STN power spectra revealed a distinct peak at approximately 7 Hz in our patient. This finding is similar to the pallidal activity seen in dystonic patients but clearly different from the subthalamic beta activity of patients with Parkinson's disease. Significant coherence between STN activity and EMG was present in the 4- to 12-Hz band in this patient. Conclusions: Dystonia is associated with pathological activity in the theta range present throughout the cortical-basal ganglia network. This activity differs from that in Parkinson's disease, suggesting that different movement disorders may involve distinct oscillatory circuit disturbances. (c) 2012 Movement Disorder Society