CEREBRAL BLOOD-FLOW IN CHRONIC COCAINE USERS - A STUDY WITH POSITRON EMISSION TOMOGRAPHY
CEREBRAL BLOOD-FLOW IN CHRONIC COCAINE USERS - A STUDY WITH POSITRON EMISSION TOMOGRAPHY
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DOI：
10.1192/bjp.152.5.641
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发表时间：
1988-05-01
影响因子：
10.5
通讯作者：
KRAJEWSKI, K
中科院分区：
文献类型：
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作者：
VOLKOW, ND;MULLANI, N;KRAJEWSKI, K
脑血管意外的发生与可卡因滥用有关。我们调查了慢性可卡因使用者和正常对照组的脑血流量（CBF）的相对分布。采用正电子发射断层扫描和15氧标记水测量相对CBF。可卡因使用者表现出CBF紊乱的区域，这可以通过他们整个大脑中有缺陷的同位素积累的斑片状区域来证明。与正常受试者相比，慢性可卡因使用者的前额叶皮层的相对CBF降低。一些可卡因使用者在戒断可卡因10天后的重复扫描继续显示出前额叶皮层的相对CBF下降。我们推测，可卡因使用者的CBF中的一些广泛的缺陷可以反映长期暴露于可卡因的拟交感神经作用的脑动脉中的血管痉挛的影响。
Occurrence of cerebrovascular accidents has been associated with cocaine abuse. We investigated the relative distribution of cerebral blood flow (CBF) in groups of chronic cocaine users, and of normal controls. Relative CBF was measured using positron emission tomography and 15oxygen-labelled water. The cocaine users showed areas of deranged CBF as evidenced by patchy regions of defective isotope accumulation throughout their brain. The chronic cocaine users showed decreased relative CBF in the prefrontal cortex when compared with normal subjects. The repeated scans of some cocaine users, after 10 days of cocaine withdrawal, continued to show decreased relative CBF of the prefrontal cortex. We hypothesize that some of the widespread defects in CBF in the cocaine users could reflect the effects of vasospasm in cerebral arteries exposed chronically to the sympathomimetic actions of cocaine.