Peroxiredoxin I (macrophage 23 kDa stress protein) is highly and widely expressed in the rat nervous system
Peroxiredoxin I (macrophage 23 kDa stress protein) is highly and widely expressed in the rat nervous system
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DOI：
10.1016/s0304-3940(00)00910-1
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发表时间：
2000-03-31
影响因子：
2.5
通讯作者：
Bannai, S
中科院分区：
文献类型：
--
作者：
Mizusawa, H;Ishii, T;Bannai, S
过氧化物酶I（Prx I），一种新的应激诱导的23 kDa的蛋白质，最初发现在巨噬细胞，在正常大鼠神经系统的表达模式进行了研究，通过免疫印迹和免疫组织化学。该蛋白在中枢和外周神经系统中广泛表达，尤其是在少突胶质细胞和雪旺细胞中。轴突和神经纤维的弱染色表明神经元过程也可能含有Prx I。神经元细胞体的免疫染色不明显。由于Prx I减少过氧化氢，Prx I的广泛神经胶质表达表明它可能在神经系统中对氧化损伤起重要的保护作用。(C)2000爱思唯尔科学爱尔兰有限公司保留所有权利。
Expression pattern of peroxiredoxin I (Prx I), a novel stress-inducible 23 kDa protein, initially found in macrophages, was investigated in the normal rat nervous system by western blot and immunohistochemistry. The protein was widely expressed in the central and peripheral nervous system, particularly in oligodendroglia and Schwann cells. Weak staining of axons and neuropil suggests neuronal processes also may contain Prx I. Immunostaining of neuronal cell bodies were not evident. Since Prx I reduces hydrogen peroxide, the widespread glial expression of Prx I indicates that it may play an important protective role against oxidative damage in the nervous system. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.