Modeling MR signal change induced by oxygen effect in neural tissue preparations of various geometries.
Modeling MR signal change induced by oxygen effect in neural tissue preparations of various geometries.
复制标题
对各种几何形状的神经组织制剂中氧效应引起的 MR 信号变化进行建模。
DOI：
10.1002/mrm.22713
复制
发表时间：
2011
影响因子：
3.3
通讯作者：
Gao,Jia-Hong
中科院分区：
文献类型：
--
作者：
Jiang,Xia;Li,Huanjie;Luo,Qingfei;Gao,Jia-Hong
组织制备最近已用于在多项基于非BOLD的功能性MRI研究中检测神经元激活，以消除血管污染。然而，由于组织激活时溶解的O2的浓度变化，在这样的系统中仍然可能发生不期望的信号变化。为了估计这种效应的影响，使用各种组织几何形状和实验参数模拟了组织溶液系统中的O2浓度分布和随后的磁化率场。我们的研究结果表明，休息和激活状态之间的大量信号变化可能会引起高含氧溶液中的O2效应，因此应谨慎解释在这样的实验中观察到的任何信号变化。Magn Reson Med，2011年。© 2010 Wiley利斯公司
Tissue preparation has recently been utilized for detection of neuronal activation in multiple non‐BOLD based functional MRI studies to eliminate vascular contamination. However, undesired signal change could still occur in such systems due to the concentration change of dissolved O2upon tissue activation. To estimate the impact of such effects, the O2concentration distribution and the consequent susceptibility field in tissue‐solution systems were simulated with various tissue geometries and experimental parameters. Our results indicate that substantial signal change between the resting and activated states could potentially be induced by the O2effect in highly oxygenated solutions, and thus caution should be taken in interpreting any signal change observed in such experiments. Magn Reson Med, 2011. © 2010 Wiley‐Liss, Inc.