Lipoic Acid: An Immunomodulator That Attenuates Glycinin-Induced Anaphylactic Reactions in a Rat Model
Lipoic Acid: An Immunomodulator That Attenuates Glycinin-Induced Anaphylactic Reactions in a Rat Model
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硫辛酸：一种免疫调节剂，可减轻大鼠模型中甘氨酸诱导的过敏反应
DOI：
10.1021/jf904403u
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发表时间：
2010-04-28
影响因子：
6.1
通讯作者：
Han, Pengfei
中科院分区：
文献类型：
--
作者：
Ma, Xi;He, Pingli;Han, Pengfei
本研究的目的是利用大鼠模型评价小剂量硫辛酸对大豆球蛋白诱导的超敏反应的缓解作用。用大豆球蛋白灌胃致敏的断奶大鼠，口服含硫辛酸12.5 mg/g的饲料。结果表明，与对照组相比，未治疗的致敏大鼠血清IgE水平、组胺释放水平、腹泻发生率和生长性能下降(P<；0.05)。硫辛酸显著(P<；0.05)改善生长性能，同时减少肥大细胞数量、血清IgE水平和组胺释放水平。补充硫辛酸改变了细胞因子的平衡，减弱了Th2型免疫应答，并改变了CD4(+)/CD8(+)T细胞的比例(P<；0.05)。我们的结果表明，小剂量的硫辛酸有可能成为一种免疫调节剂，以防止大豆诱导的过敏。
The purpose of this study was to evaluate the attenuation effects of consuming a small dose of lipoic acid on soybean glycinin-induced hypersensitivity using a rat model. Sensitized by gavage with glycinin, weaned rats were orally supplemented with the diet containing 12.5 mu g of lipoic acid/g (per diet). Results showed that untreated, sensitized rats demonstrated an increase in the level of serum IgE, the level of histamine release, and incidence of diarrhea and reduced growth performance compared with the controls (P < 0.05). Lipoic acid significantly (P < 0.05) improved growth performance while reducing mast cell numbers, the level of serum IgE, and the level of histamine release. Lipoic acid supplementation altered the balance of cytokines, attenuated the Th2-type immune response, and amended the ratio of CD4(+) to CD8(+) T cells (P < 0.05). Our results suggest that a small dose of lipoic acid has the potential to be an immunomodulator to prevent soybean-induced allergies.