A Convergent Synthesis of AR-C123196 Utilising Reaction Between a Cyclic Carbonate and a Phenol for Aryl Alkyl Ether Formation
A Convergent Synthesis of AR-C123196 Utilising Reaction Between a Cyclic Carbonate and a Phenol for Aryl Alkyl Ether Formation
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DOI：
10.1021/op9000687
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发表时间：
2009-07-01
影响因子：
3.4
通讯作者：
Singleton, John T.
中科院分区：
文献类型：
--
作者：
Allsop, Glyn L.;Cole, Andrea J.;Singleton, John T.
报道了AR-C123196的一种收敛合成方法，它是通过酚羟基对环状碳酸酯的亲核攻击而形成烷基芳醚键的。这种方法在几千公斤的规模上成功地进行了操作。
The development of a convergent synthesis of AR-C123196 is reported in which the alkyl aryl ether linkage was formed by nucleophilic attack of a phenolic hydroxyl group onto a cyclic carbonate. This approach was successfully operated on a multikilogram scale.