Posttranscriptional and posttranslational regulation of clock genes
Posttranscriptional and posttranslational regulation of clock genes
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DOI：
10.1177/0748730404268111
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发表时间：
2004-10-01
影响因子：
3.5
通讯作者：
Saez, L
中科院分区：
文献类型：
--
作者：
Harms, E;Kivimäe, S;Saez, L
在包括植物、动物、细菌和真菌在内的各种生物中都观察到了昼夜节律。在这样的生物体中，生物钟主要由一个细胞自主的转录反馈环组成。除了转录调控外，核心时钟转录本和蛋白质的修饰还可以极大地影响生物钟。在这篇综述中，作者讨论了一些转录后和翻译后修饰及其对生物钟的影响。这些修改的组合结果是调整时钟的定时，以产生大约需要24小时的昼夜节律振荡器。
Circadian rhythms have been observed in diverse organisms, including plants, animals, bacteria, and fungi. In such organisms, the circadian clock is primarily composed of a cell-autonomous transcriptional feedback loop. In addition to transcriptional regulation, the modification of core clock transcripts and proteins can dramatically affect the circadian clock. In this review, the authors discuss some of the posttranscriptional and posttranslational modifications and their effects on the circadian clock. The combined outcome of these modifications is to adjust the timing of the clock to produce a circadian oscillator that takes approximately 24 h.