Effectiveness of HBV vaccination in infants and prediction of HBV prevalence trend under new vaccination plan: findings of a large-scale investigation.
Effectiveness of HBV vaccination in infants and prediction of HBV prevalence trend under new vaccination plan: findings of a large-scale investigation.
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婴儿乙型肝炎疫苗接种的有效性及新疫苗接种计划下乙型肝炎病毒流行趋势的预测：大规模调查结果
DOI：
10.1371/journal.pone.0047808
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Li L
中科院分区：
文献类型：
--
作者：
Yang SG;Wang B;Chen P;Yu CB;Deng M;Yao J;Zhu CX;Ren JJ;Wu W;Ju B;Shen JF;Chen Y;Li MD;Ruan B;Li L
背景B型肝炎病毒（HBV）感染仍然是一个严重的公共卫生问题。调查其流行程度和趋势对预防至关重要。方法评价1992年婴儿乙肝疫苗接种的效果，预测2011年各年龄段乙肝疫苗接种的流行趋势。我们对浙江省12个县的761，544名居民进行了基于社区的调查，根据他们的地理位置，人口密度和经济发展水平进行了选择。采用时移法预测HBV流行趋势。检测血清乙型肝炎病毒表面抗原（HBsAg）和丙氨酸氨基转移酶（ALT）。结果在761,544例HBsAg筛查者中，阳性54,132例（调整后携带率为6.13%），ALT升高和HBsAg阳性9,455例（标化率为1.18%）。≤20岁人群标化HBsAg携带率为1.51%。影响乙肝病毒感染的主要因素是性别、年龄、家族史、饮酒、吸烟、打工和职业。根据2011年实施的疫苗接种计划，我们预测到2020年，HBsAg携带率为5.27%，≤34岁人群HBsAg携带率将达到WHO标准的2%低流行上限，标化率为1.86%。结论1992年实施的全国婴儿乙肝疫苗接种计划，使婴儿HBV感染率明显下降。2011年的计划很可能将浙江省的HBV感染率降低到低中度流行水平，预计到2020年围产期传播将得到控制。
Background Hepatitis B virus (HBV) infection remains a severe public health problem. Investigating its prevalence and trends is essential to prevention. Methods To evaluate the effectiveness of HBV vaccination under the 1992 Intervention Program for infants and predicted HBV prevalence trends under the 2011 Program for all ages. We conducted a community-based investigation of 761,544 residents of 12 counties in Zhejiang Province selected according to their location, population density, and economic development. The HBV prevalence trends were predicted by a time-shifting approach. HBV surface antigen (HBsAg) and alanine amino transferase (ALT) were determined. Results Of the 761,544 persons screened for HBsAg, 54,132 were positive (adjusted carrier rate 6.13%); 9,455 had both elevated ALT and a positive HBsAg test (standardized rate 1.18%). The standardized HBsAg carrier rate for persons aged ≤20 years was 1.51%. Key factors influencing HBV infection were sex, age, family history, drinking, smoking, employment as a migrant worker, and occupation. With the vaccination program implemented in 2011, we predict that by 2020, the HBsAg carrier rate will be 5.27% and that for individuals aged ≤34 years will reach the 2% upper limit of low prevalence according to the WHO criteria, with a standardized rate of 1.86%. Conclusions The national HBV vaccination program for infants implemented in 1992 has greatly reduced the prevalence of HBV infection. The 2011 program is likely to reduce HBV infection in Zhejiang Province to a low moderate prevalence, and perinatal transmission is expected to be controlled by 2020.
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影响因子：
25.7
作者：
Lai, Michelle;Hyatt, Benjamin J.;Afdhal, Nezam H.
通讯作者：
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