Successful treatment of seizure disorder by evaluating phenobarbital clearance in a paediatric patient undergoing continuous haemodiafiltration.
Successful treatment of seizure disorder by evaluating phenobarbital clearance in a paediatric patient undergoing continuous haemodiafiltration.
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通过评估接受连续血液透析滤过的儿科患者的苯巴比妥清除率，成功治疗癫痫症。
DOI：
10.1111/jcpt.12815
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Ishii I
中科院分区：
文献类型：
--
作者：
Suzuki T;Suzuki T;Takatsuka H;Yamazaki S;Ishii I
什么是已知的和客观的：连续性血液透析滤过（CHDF）期间苯巴比妥（PB）剂量的确定需要对患者自身清除率和CHDF清除率进行评价。病例描述：采用Sawchuk-Zaske方法计算了一例接受CHDF的9岁Dravet综合征女性患者的PB全身清除率，CHDF清除率计算为内流和外流PB水平之间的差异，并根据血液净化条件进行了调整。剂量调整可控制癫痫发作。什么是新的和结论：通过评估患者自身PB清除率以及CHDF清除率来调整PB剂量，可准确控制PB水平并减少癫痫发作的发生。
What is known and objective: Determination of phenobarbital (PB) dosing during continuous haemodiafiltration (CHDF) requires evaluation of both the patient's own clearance and CHDF clearance. Case description: Systemic clearance of PB in a 9‐year‐old female patient with Dravet syndrome, who was undergoing CHDF, was calculated by the Sawchuk‐Zaske method, and clearance by CHDF was calculated as the difference between PB levels in influx and efflux, adjusted for the blood purification conditions. Dosage adjustment produced seizure control. What is new and conclusion: Adjusting PB dose by evaluating the patient's own PB clearance as well as that by CHDF resulted in accurate control of PB level and a reduction in the occurrence of seizures.