Validity of self reported diagnoses of cancer in a major Spanish prospective cohort study
Validity of self reported diagnoses of cancer in a major Spanish prospective cohort study
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DOI：
10.1136/jech.2005.039131
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发表时间：
2006-07-01
影响因子：
6.3
通讯作者：
Gonzalez, C. A.
中科院分区：
文献类型：
--
作者：
Navarro, C.;Chirlaque, M. D.;Gonzalez, C. A.
简介：本研究的目的是评估的有效性，自我报告的诊断癌症的人招募的西班牙EPIC（欧洲癌症和营养的前瞻性调查）队列study，并确定变量与正确报告的诊断cancer.Methods：41 440成员EPIC被问到在招聘时，他们是否已被诊断为癌症和一年的诊断和网站。验证自我报告的癌症诊断的过程包括将队列数据库与基于人群的癌症登记处的数据进行比较。计算癌症诊断有效性测试。一个正确的报告和某些社会人口，肿瘤相关的，或健康相关的变量之间的关联进行了Logistic regression.Results分析：自我报告的癌症诊断的整体敏感性低（57.5%; 95%CI：51.9至63.0），最高值显示的人具有较高的教育水平或癌症家族史和吸烟者的最低值。乳腺癌和甲状腺癌的诊断有效性最高，子宫癌、膀胱癌和结肠直肠癌的诊断有效性最低。在两种性别的变量显示一个显着的关联与正确的报告的癌症是：高等教育水平，以前的病理，侵袭性肿瘤的数量，并在妇女中，历史的妇科surgical.Conclusions：自我报告的诊断癌症的整体敏感性是比较低的，它不建议在流行病学研究中识别肿瘤。然而，自我报告的诊断可能对某些肿瘤部位、恶性行为和中等至高等教育水平高度有效。
Introduction: This study aims to assess the validity of self reported diagnoses of cancer by persons recruited for the Spanish EPIC ( European prospective investigation into cancer and nutrition) cohort study and to identify variables associated with correctly reporting a diagnosis of cancer.Methods: 41 440 members of EPIC were asked at the time of recruitment whether they had been diagnosed with cancer and the year of diagnosis and site. The process of validating self reported diagnoses of cancer included comparison of the cohort database with the data from the population based cancer registries. Cancer diagnostic validity tests were calculated. The association between a correct report and certain sociodemographic, tumour related, or health related variables were analysed by logistic regression.Results: The overall sensitivity of self reported diagnoses of cancer is low (57.5%; 95% CI: 51.9 to 63.0), the highest values being shown by persons with a higher level of education or with a family history of cancer and the lowest values by smokers. Breast and thyroid cancers are those with the highest diagnostic validity and uterus, bladder, and colon-rectum those with the lowest. In both sexes the variables showing a significant association with a correct report of cancer are: higher education level, number of previous pathologies, invasive tumour, and, in women, a history of gynaecological surgery.Conclusions: The overall sensitivity of self reported diagnoses of cancer is comparatively low and it is not recommended in epidemiological studies for identifying tumours. However, self reported diagnoses might be highly valid for certain tumour sites, malignant behaviour, and average to high levels of education.