Decreasing ELK3 expression improves Bone Morphogenetic Protein Receptor 2 signaling and pulmonary vascular cell function in PAH.

Decreasing ELK3 expression improves Bone Morphogenetic Protein Receptor 2 signaling and pulmonary vascular cell function in PAH.
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减少 ELK3 表达可改善 PAH 中的骨形态发生蛋白受体 2 信号传导和肺血管细胞功能。

DOI:
10.1101/2023.01.14.524023
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发表时间:
2023
期刊:
bioRxiv : the preprint server for biology
影响因子:
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通讯作者:
Spiekerkoetter,EddaF
Spiekerkoetter,EddaF
中科院分区:
--
文献类型:
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作者:
Ali,MdKhadem;Zhao,Lan;deJesusPerez,Vinicio;Nicolls,MarkR;Spiekerkoetter,EddaF

文献摘要

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ELK3在PAH患者的血液和肺血管细胞中上调,可能通过调节BMPR2信号在PAH中发挥重要作用。
ELK3 is upregulated in blood and pulmonary vascular cells of PAH patients and may play a significant role in PAH potentially through modulating BMPR2 signaling.