Zika virus infection of Hofbauer cells.
Zika virus infection of Hofbauer cells.
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DOI：
10.1111/aji.12613
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发表时间：
2017-02
期刊：
影响因子：
--
通讯作者：
Guller S
中科院分区：
文献类型：
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作者：
Simoni MK;Jurado KA;Abrahams VM;Fikrig E;Guller S
最近的研究表明，寨卡病毒（ZIKV）的产前感染与包括小头畸形在内的主要胎儿和新生儿不良结局有关。越来越多的人认为存在先天性寨卡综合征（CZS）。先前的研究表明，非胎盘巨噬细胞在登革热病毒（DENV）的复制中起关键作用，DENV是一种密切相关的黄病毒。由于胎盘为某些病毒的垂直传播提供了通道，而胎盘霍夫鲍尔细胞（HBCs）是位于胎儿毛细血管附近的胎儿-胎盘巨噬细胞，因此最近几项研究检测了寨卡病毒感染HBCs也就不足为奇了。在这篇综述中，我们描述了与寨卡病毒感染相关的先天性异常，乙肝病毒在胎盘对感染反应中的作用，以及乙肝病毒对寨卡病毒感染易感性的证据。我们的结论是，乙肝病毒可能有助于寨卡病毒在胎盘中的传播，并促进寨卡病毒的垂直传播，最终损害胎儿和新生儿的发育和功能。目前的证据强烈表明，有必要进一步研究寨卡病毒感染乙肝病毒的具体分子机制及其对cz发展的潜在影响。
Recent studies have linked antenatalinfection with Zika virus (ZIKV) with major adverse fetal and neonatal outcomes, including microcephaly. There is a growing consensus for the existence of a congenital Zika syndrome (CZS). Previous studies have indicated that non-placental macrophages play a key role in the replication of Dengue virus (DENV), a closely related flavivirus. Since the placenta provides the conduit for vertical transmission of certain viruses, and placental Hofbauer cells (HBCs) are fetal-placental macrophages located adjacent to fetal capillaries, it is not surprising that several recent studies have examined infection of HBCs by ZIKV. In this review we describe congenital abnormalities associated with ZIKV infection, the role of HBCs in the placental response to infection, and evidence for the susceptibility of HBCs to ZIKV infection. We conclude that HBCs may contribute to the spread of ZIKV in placenta and promote vertical transmission of ZIKV, ultimately compromising fetal and neonatal development and function. Current evidence strongly suggests that further studies are warranted to dissect the specific molecular mechanism through which ZIKV infects HBCs and its potential impact on the development of CZS.