Immuno-polymeric nanoparticles by Diels-Alder chemistry
Immuno-polymeric nanoparticles by Diels-Alder chemistry
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DOI：
10.1002/anie.200701032
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发表时间：
2007-01-01
影响因子：
16.6
通讯作者：
Shoichet, Molly S.
中科院分区：
文献类型：
--
作者：
Shi, Meng;Wosnick, Jordan H.;Shoichet, Molly S.
聚(2-甲基-2-苄氧基羰基三亚甲基碳酸酯-co-D, L-丙交酯)(聚(TMCC-co-LA)) 3 的合成： 1H NMR (CDCl3, 300 MHz): δ 1.20-1.30 ppm (bm, TMC 链段的 CH3 质子), δ 1.35-1.55 ppm (bm, TMC 链段的 CH3 质子) LA 段），δ 4.10-4.30 ppm（bm，TMC 段的 CH2 质子），δ 5.05-5.25 ppm（bm，LA 段的 CH 质子），δ 7.35 ppm（bm，Ar）。 Mn= 15.8 kDa，PDI= 2.3。通过配备三重检测器阵列(Viscotek TDA302)的GPC(Viscotek VE2001 GPCmax)表征分子量。使用四氢呋喃 (THF) 作为流动相，流速为 1 mL/min，相对于聚苯乙烯标准品计算分子量。苄基保护的 TMCC 和 LA 含量分别为 13 mol.% 和 87 mol.%（表 S1a）。共聚物中TMCC和LA链段之间的摩尔比通过两种单体的进料比进行调节，并通过将δ 1.20-1.30 ppm处的信号积分与分别源自TMCC和LA链段中的甲基的δ 1.35-1.55 ppm处测量的信号积分进行比较来计算。
Synthesis of poly (2-methyl-2-benzyloxycarbonyltrimethylene carbonate-co-D, L-lactide)(poly (TMCC-co-LA)) 3: 1H NMR (CDCl3, 300 MHz): δ 1.20-1.30 ppm (bm, CH3 protons of the TMC segments), δ 1.35-1.55 ppm (bm, CH3 protons of the LA segments), δ 4.10-4.30 ppm (bm, CH2 protons of the TMC segments), δ 5.05-5.25 ppm (bm, CH protons of the LA segments), δ 7.35 ppm (bm, Ar). Mn= 15.8 kDa and PDI= 2.3. Molecular weight was characterized by a GPC (Viscotek VE2001 GPCmax) equipped with a triple detector array (Viscotek TDA302). Using tetrahydrofuran (THF) as mobile phase at a flow rate of 1 mL/min, molecular weight was calculated relative to polystyrene standards. Benzyl protected TMCC and LA contents are 13 mol.% and 87 mol.%, respectively (Table S1a). The molar ratio between TMCC and LA segments in the copolymer was adjusted by the feed ratio of the two monomers, and was calculated by comparing the integral of the signals at δ 1.20-1.30 ppm with those measured at δ 1.35-1.55 ppm, originating from the methyl groups in the TMCC and LA segments, respectively.