Higher-functioning pervasive developmental disorders: Rates and patterns of psychotropic drug use
Higher-functioning pervasive developmental disorders: Rates and patterns of psychotropic drug use
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DOI：
10.1097/00004583-199907000-00024
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发表时间：
1999-07-01
影响因子：
13.3
通讯作者：
Volkmar, FR
中科院分区：
文献类型：
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作者：
Martin, A;Scahill, L;Volkmar, FR
目的：探讨高功能广泛性发育障碍（HFPDDs）受试者使用精神药物的频率、特征和相关目标症状。方法：共有109名儿童，青少年和成人（平均年龄= 13.9岁，SD = 6.9）连续寻求入组耶鲁大学儿童研究中心的社会学习障碍项目纳入本研究。个体中，谁的自闭症，自闭症，或广泛性发育障碍-没有另行说明以前已被诊断，谁有记录的全量表智商大于或等于70完成调查人口统计学，临床和用药史信息。为了自然地评价该人群的药物使用模式，分析了每种药物类别的人口统计学和临床变量。结果：55%的受试者服用精神药物，29.3%的受试者同时服用2种或2种以上药物。抗抑郁药是最常用的药物（32.1%），其次是兴奋剂（20.2%）和神经安定药（16.5%）。服用精神药物的受试者的临床表现是异质性的，最一致的包括焦虑相关的目标症状（65%的用药个体）。结论：精神药物的使用似乎是常见的HFPDDs的受试者，但一般不基于实证研究的结果。治疗受试者的临床异质性表明，精神科合并症可能会被忽视，在这一人群。
Objective: To explore the frequency, characteristics, and associated target symptoms of psychotropic drug use among subjects with higher-functioning pervasive developmental disorders (HFPDDs). Method: A total of 109 children, adolescents, and adults (mean age = 13.9 years, SD = 6.9) consecutively seeking enrollment into the Yale Child Study Center's Project on Social Learning Disabilities were included in the study. Individuals in whom Asperger's disorder, autism, or pervasive developmental disorder-not otherwise specified had been previously diagnosed and who had a documented Full Scale IQ greater than or equal to 70 completed surveys on demographic, clinical, and medication history information. To naturalistically evaluate medication use patterns in this population, each drug class was analyzed with respect to demographic and clinical variables. Results: In all, 55% of subjects were taking psychotropics, with 29.3% taking 2 or more medications simultaneously. Antidepressants were the most commonly used agents (32.1%), followed by stimulants (20.2%) and neuroleptics (16.5%). The clinical presentation of subjects taking psychotropic agents was heterogeneous, and most consistently included anxiety-related target symptoms (in 65% of medicated individuals). Conclusions: Psychotropic medication use appears to be common among subjects with HFPDDs, yet not generally based on the results of empirical research. Clinical heterogeneity among treated subjects suggests that psychiatric comorbidity may be overlooked in this population.