Delivery of infection from asymptomatic carriers of COVID-19 in a familial cluster
Delivery of infection from asymptomatic carriers of COVID-19 in a familial cluster
复制标题
DOI：
10.1016/j.ijid.2020.03.042
复制
发表时间：
2020-05-01
影响因子：
8.4
通讯作者：
Xu, Xuejun
中科院分区：
文献类型：
--
作者：
Ye, Feng;Xu, Shicai;Xu, Xuejun
目标：随着COVID-19在全球持续爆发，其已成为全球健康问题。此前的一项研究报告了一个无症状传播COVID-19的家庭集群。在这里，我们报告了另一系列病例，并进一步证明了症状前携带者传播COVID-19的可重复性。方法：在医院招募了一个由5名COVID-19相关患者组成的家族性集群。结果：3例患者家属（病例3/4/5）均为武汉回国人员，其中3例为武汉回国人员，3例为武汉回国人员，3例为武汉回国人员。此外，两名未前往武汉的家庭成员在与其他三名家庭成员接触后也感染了COVID-19。例1发生重症肺炎，入住ICU。例3和例5在住院第2 ~ 3天出现发热、咳嗽，肺部有毛玻璃样改变。例4入院后出现腹泻、咽痛等症状，影像学无异常。病例2无临床或影像学异常。所有5例患者的C反应蛋白水平均升高。结论：我们的研究结果表明，COVID-19可以由潜伏期内的无症状携带者传播。(C)2020作者（S）由爱思唯尔有限公司代表国际传染病学会出版。
Objectives: With the ongoing outbreak of COVID-19 around the world, it has become a worldwide health concern. One previous study reported a family cluster with an asymptomatic transmission of COVID-19. Here, we report another series of cases and further demonstrate the repeatability of the transmission of COVID-19 by pre-symptomatic carriers.Methods: A familial cluster of five patients associated with COVID-19 was enrolled in the hospital. We collected epidemiological and clinical characteristics, laboratory outcomes from electronic medical records, and also verified them with the patients and their families.Results: Among them, three family members (Case 3/4/5) had returned from Wuhan. Additionally, two family members, those who had not traveled to Wuhan, also contracted COVID-19 after contacting with the other three family members. Case 1 developed severe pneumonia and was admitted to the ICU. Case 3 and Case 5 presented fever and cough on days two through three of hospitalization and had ground-glass opacity changes in their lungs. Case 4 presented with diarrhea and pharyngalgia after admission without radiographic abnormalities. Case 2 presented no clinical nor radiographic abnormalities. All five cases had an increasing level of C-reactive protein.Conclusions: Our findings indicate that COVID-19 can be transmitted by asymptomatic carriers during the incubation period. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.