Chitin Is a Size-Dependent Regulator of Macrophage TNF and IL-10 Production
Chitin Is a Size-Dependent Regulator of Macrophage TNF and IL-10 Production
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DOI：
10.4049/jimmunol.0802113
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发表时间：
2009-03-15
影响因子：
4.4
通讯作者：
Elias, Jack A.
中科院分区：
文献类型：
--
作者：
Da Silva, Carla A.;Chalouni, Cecile;Elias, Jack A.
甲壳素是真菌、昆虫和寄生虫中普遍存在的一种多糖。我们假设甲壳素是一种大小依赖的先天免疫调节因子。为了验证这一假设，我们表征了不同大小的几丁质对小鼠肺泡巨噬细胞或腹膜巨噬细胞的影响。在这些研究中，大的甲壳素碎片是惰性的，而中等大小的甲壳质(40-70微米)和小的甲壳质(SC；
Chitin is a ubiquitous polysaccharide in fungi, insects, and parasites. We hypothesized that chitin is a size-dependent regulator of innate immunity. To test this hypothesis, we characterized the effects of chitins of different sizes on murine bronchoalveolar or peritoneal macrophages. In these studies, large chitin fragments were inert, while both intermediate-sized chitin (40-70 mu m) and small chitin (SC;