Coronary risk factors measured in childhood and young adult life are associated with coronary artery calcification in young adults: The muscatine study
Coronary risk factors measured in childhood and young adult life are associated with coronary artery calcification in young adults: The muscatine study
复制标题
DOI：
10.1016/0735-1097(95)00461-0
复制
发表时间：
1996-02-01
影响因子：
24
通讯作者：
Lauer, RM
中科院分区：
文献类型：
--
作者：
Mahoney, LT;Burns, TL;Lauer, RM
目标.本研究旨在评估年轻成年男性和女性冠状动脉钙化的患病率，并检查冠状动脉钙化的存在与儿童和年轻成年人生活中测量的冠状动脉危险因素之间的关联。电子束计算机断层扫描是检测冠状动脉钙化的一种敏感、无创的方法，冠状动脉钙化是动脉粥样硬化过程的一个标志。受试者（197名男性，187名女性）在儿童期（平均年龄15岁）和青年期（平均年龄27岁和33岁）测量了冠状动脉危险因素。每个人都在第二次年轻成人检查时接受了电子束计算机断层扫描研究。冠状动脉钙化的患病率男性为31%，女性为10%。体型增大、血压升高和高密度脂蛋白（HDL）胆固醇水平降低是与冠状动脉钙化最密切相关的冠状动脉风险因素，分别在平均年龄33岁的男性和女性中使用标准化风险因素测量，体重指数最高十分位数分别为6.4和13.6，收缩压最高十分位数分别为6.4和6.4，HDL胆固醇最低十分位数分别为4.3和4.7。冠状动脉钙化在年轻成人人群中男性更常见。在儿童和年轻人中测量的冠状动脉危险因素与冠状动脉钙化的早期发展相关。在儿童和青年生活期间测量的体重指数增加以及在青年生活期间测量的血压升高和HDL胆固醇水平降低与年轻人冠状动脉钙化的存在相关。
Objectives. This study was designed to estimate the prevalence of coronary artery calcification in young adult men and women and to examine the association between the presence of coronary artery calcification and coronary risk factors measured in childhood and young adult life.Background. Electron beam computed tomography is a sensitive, noninvasive method for detecting coronary artery calcification, a marker of the atherosclerotic process, Coronary artery calcification is associated with coronary risk factors in older adults.Methods. Subjects (197 men, 187 women) had coronary risk factors measured in childhood (mean age 15 years) and twice during young adult life (mean ages 27 and 33 years). Each underwent an electron beam computed tomographic study at their second young adult examination.Results. The prevalence of coronary artery calcification was 31% in men and 10% in women. Increased body size, increased blood pressure and decreased high density lipoprotein (HDL) cholesterol levels were the coronary risk factors that showed the strongest association with coronary artery calcification, Significant odds ratios for coronary artery calcification, using standardized risk factor measurements at a mean age of 33 years in men and women, respectively, were 6.4 and 13.6 for the highest decile of body mass index, 6.4 and 6.4 for the highest decile of systolic blood pressure and 4.3 and 4.7 for the lowest decile of HDL cholesterol.Conclusions. Coronary artery calcification is more prevalent in men in this young adult population. Coronary risk factors measured in children and young adults are associated with the early development of coronary artery calcification. Increased body mass index measured during childhood and young adult life and increased blood pressure and decreased HDL cholesterol levels measured during young adult life are associated with the presence of coronary artery calcification in young adults.