A genomic search for linkage of neurofibromatosis to RFLPs.
A genomic search for linkage of neurofibromatosis to RFLPs.
复制标题
神经纤维瘤病与 RFLP 关联的基因组搜索。
DOI：
10.1136/jmg.24.9.536
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发表时间：
1987
影响因子：
4
通讯作者：
Willard,H
中科院分区：
文献类型：
--
作者：
Barker,D;Wright,E;Nguyen,K;Cannon,L;Fain,P;Goldgar,D;Bishop,DT;Carey,J;Kivlin,J;Willard,H
我们最初尝试将NF定位在4号和19号染色体上，这两个染色体在之前的报道中都为连锁提供了积极的证据。该分析没有显示任何证据支持这两种假设。我们绘制NF图谱的第二次尝试是对基因组进行一般搜索，分析一组根据多态性程度、染色体位置、易用性和可用性选择的标记。连锁分析的数据来自17个分离NF基因的多重家族。采用PAP进行连锁分析。值得注意的是，当NF与17号染色体着丝粒的重组分数为0.1时，lod评分为+1.17。
Our initial attempt to map NF was directed towards chromosomes 4 and 19, both of which had provided positive evidence for linkage in previous reports. This analysis showed no evidence in support of either hypothesis. Our second attempt at mapping NF was a general search of the genome, analysing a set of markers selected according to their degree of polymorphism, chromosomal location, ease of use, and availability. Data for linkage analysis were obtained from 17 multiplex families which are segregating a gene for NF. Linkage analyses were performed using PAP. Of note is the lod score of +1.17 at a recombination fraction of 0.1 between NF and the centromere of chromosome 17.