Medial Temporal Lobe Contributions to Episodic Future Thinking: Scene Construction or Future Projection?
Medial Temporal Lobe Contributions to Episodic Future Thinking: Scene Construction or Future Projection?
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DOI：
10.1093/cercor/bhw381
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发表时间：
2018-02-01
期刊：
影响因子：
3.7
通讯作者：
Verfaellie, M.
中科院分区：
文献类型：
--
作者：
Palombo, D. J.;Hayes, S. M.;Verfaellie, M.
先前的研究表明，当人们思考未来时，内侧颞叶（MTL）的参与度比思考现在时更高，这表明未来投射驱动了MTL的参与度。然而，未来的思维任务往往涉及场景处理，留下开放的替代可能性，场景建设的需求，而不是未来的投影，负责先前的工作中观察到的MTL差异。本研究探讨了这种替代帐户。使用功能磁共振成像，我们直接对比了MTL活动：1）在未来思维需求中匹配的高场景构建和低场景构建想象条件，以及2）在场景构建需求中匹配的面向未来和面向现在的想象条件。与替代账户一致，MTL在高场景构建条件下比在低场景构建条件下更活跃。相比之下，MTL的差异没有观察到比较未来与现在的条件。此外，MTL激活的程度与参与者想象场景的程度有关，但与参与者思考未来的程度无关。这些发现有助于消除歧义的想象过程的组成部分，具体涉及MTL。
Previous research has shown that the medial temporal lobes (MTL) are more strongly engaged when individuals think about the future than about the present, leading to the suggestion that future projection drives MTL engagement. However, future thinking tasks often involve scene processing, leaving open the alternative possibility that scene-construction demands, rather than future projection, are responsible for the MTL differences observed in prior work. This study explores this alternative account. Using functional magnetic resonance imaging, we directly contrasted MTL activity in 1) high scene-construction and low scene-construction imagination conditions matched in future thinking demands and 2) future-oriented and present-oriented imagination conditions matched in scene-construction demands. Consistent with the alternative account, the MTL was more active for the high versus low scene-construction condition. By contrast, MTL differences were not observed when comparing the future versus present conditions. Moreover, the magnitude of MTL activation was associated with the extent to which participants imagined a scene but was not associated with the extent to which participants thought about the future. These findings help disambiguate which component processes of imagination specifically involve the MTL.