Gender-Related Differences in Clinical Presentation and Angiographic Findings in Patients with Ischemia and No Obstructive Coronary Artery Disease (INOCA): A Single-Center Observational Registry
Gender-Related Differences in Clinical Presentation and Angiographic Findings in Patients with Ischemia and No Obstructive Coronary Artery Disease (INOCA): A Single-Center Observational Registry
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DOI：
10.1055/s-0040-1709500
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发表时间：
2020-12-01
影响因子：
0.6
通讯作者：
Al-Lamee, Rasha
中科院分区：
文献类型：
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作者：
Gitto, Mauro;Gentile, Francesco;Al-Lamee, Rasha
缺血性和非阻塞性冠状动脉（INOCA）是一种常见的临床表现，其原因多种多样，在常规临床实践中往往没有得到充分研究。我们研究的目的是描述INOCA患者的真实人群，更深入地关注症状和压力测试结果。研究人群包括435例因心绞痛症状和/或非侵入性成像心肌缺血证据接受诊断性冠状动脉造影的患者。在所有患者中，血管造影显示非阻塞性冠状动脉疾病（CAD，管腔直径狭窄小于30%或血流储备分数>0.8和/或瞬时无波比率>0.89）。54%的患者是女性。非典型临床表现在女性中更常见（59.5% vs. 49.5%，p =0.037）。女性冠状动脉正常的可能性高于男性（41.8%对16.2%，p
Ischemia and no obstructive coronary arteries (INOCA) is a common clinical presentation, with a variety of causes that are often not fully investigated in routine clinical practice. The goal of our study was to characterize a real-world population of patients with INOCA, with a deeper focus on symptoms and stress test findings. The study population consisted of 435 patients who underwent diagnostic coronary angiography for anginal symptoms and/or evidence of myocardial ischemia at non-invasive imaging. In all patients angiography demonstrated nonobstructive coronary artery disease (CAD, less than 30% luminal diameter stenosis or fractional flow reserve>0.8 and/or instantaneous wave-free ratio >0.89). Fifty-four percent of the patients were women. Atypical clinical presentation was more common in women (59.5 vs. 49.5%, p =0.037). Women were more likely to have normal coronary arteries than men (41.8 vs. 16.2%, p