Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation.
Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation.
复制标题
神经干细胞维持自然杀伤细胞的作用，从而控制大脑炎症的恢复
DOI：
10.1038/nn.4211
复制
发表时间：
2016-02
影响因子：
25
通讯作者：
Shi FD
中科院分区：
文献类型：
--
作者：
Liu Q;Sanai N;Jin WN;La Cava A;Van Kaer L;Shi FD
器官特异性自身免疫性疾病的恢复在很大程度上依赖于内源性修复机制和控制它们的局部因素的动员。自然杀伤（NK）细胞被自身免疫迅速动员到目标器官，通常在炎症减弱时进行数值收缩。我们报告了意想不到的发现，NK细胞在人类和小鼠多发性硬化症的慢性期保留在脑室下区（SVZ）。这些NK细胞被发现优先靠近SVZ神经干细胞（NSCs），后者产生白细胞介素-15并维持功能正常的NK细胞。此外，NK细胞限制了脑炎症后NSCs的修复能力。这些发现揭示了NSCs和NK细胞之间的相互作用调节神经修复。
Recovery from organ-specific autoimmune diseases largely relies on the mobilization of endogenous repair mechanisms and local factors that control them. Natural killer (NK) cells are swiftly mobilized to organs targeted by autoimmunity and typically undergo numerical contraction when inflammation wanes. We report the unexpected finding that NK cells are retained in the brain subventricular zone (SVZ) during the chronic phase of multiple sclerosis in humans and its animal model in mice. These NK cells were found preferentially in close proximity to SVZ neural stem cells (NSCs) that produce interleukin-15 and sustain functionally competent NK cells. Moreover, NK cells limited the reparative capacity of NSCs following brain inflammation. These findings reveal that reciprocal interactions between NSCs and NK cells regulate neurorepair.