Viewing Ambiguous Social Interactions Increases Functional Connectivity between Frontal and Temporal Nodes of the Social Brain.
Viewing Ambiguous Social Interactions Increases Functional Connectivity between Frontal and Temporal Nodes of the Social Brain.
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DOI：
10.1523/jneurosci.0870-20.2021
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发表时间：
2021-07-14
期刊：
影响因子：
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通讯作者：
Bell AH
中科院分区：
文献类型：
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作者：
Ainsworth M;Sallet J;Joly O;Kyriazis D;Kriegeskorte N;Duncan J;Schüffelgen U;Rushworth MFS;Bell AH
社会行为是由大脑区域网络协调的，包括那些参与社会刺激感知的区域和那些参与复杂功能的区域，例如推断知觉和精神状态以及控制社会互动。许多这些孤立区域的属性和功能相对较好地被理解，但对于这些区域在处理动态社会互动时如何相互作用却知之甚少。为了研究大脑区域之间的功能连接是否受到社会环境的调节，我们收集了雄性猴子（Macaca mulatta）观看标记为“亲和”、“攻击性”或“模糊”的社交互动视频的功能磁共振成像数据。我们展示了与沿颞上沟、顶叶皮层、内侧和外侧额叶皮层以及尾状核两侧的社会互动感知相关的激活。在这个网络中，我们发现额颞叶功能连接受到社会环境的显着调节。至关重要的是，我们将对特定行为的观察与网络内功能连接的变化联系起来。观察攻击性行为与颞颞连接的有限增加和扣带回颞连接的微弱增加有关。相比之下，观察结果不确定的交互与颞颞和扣带回颞功能连接的显着增加相关。我们假设，当扣带回和颞区在做出更困难的社会推理时协调其活动时，就会发生这种广泛的网络同步。意义陈述 处理来自环境的社会信息需要激活几个大脑区域，这些区域集中在额叶和颞叶。然而，人们对这些区域如何相互作用以促进不同社交互动的处理知之甚少。在这里，我们表明额叶和颞叶内部和之间的功能连接受到社会背景的调节。具体来说，我们证明，观察结果不清楚的社交互动与扣带皮层和颞叶皮层内部和之间的同步性增加有关。这些发现表明，当进行更困难的社会推理时，扣带皮层和颞叶皮层之间的协调性会增强。
Social behavior is coordinated by a network of brain regions, including those involved in the perception of social stimuli and those involved in complex functions, such as inferring perceptual and mental states and controlling social interactions. The properties and function of many of these regions in isolation are relatively well understood, but less is known about how these regions interact while processing dynamic social interactions. To investigate whether the functional connectivity between brain regions is modulated by social context, we collected fMRI data from male monkeys (Macaca mulatta) viewing videos of social interactions labeled as “affiliative,” “aggressive,” or “ambiguous.” We show activation related to the perception of social interactions along both banks of the superior temporal sulcus, parietal cortex, medial and lateral frontal cortex, and the caudate nucleus. Within this network, we show that fronto-temporal functional connectivity is significantly modulated by social context. Crucially, we link the observation of specific behaviors to changes in functional connectivity within our network. Viewing aggressive behavior was associated with a limited increase in temporo-temporal and a weak increase in cingulate-temporal connectivity. By contrast, viewing interactions where the outcome was uncertain was associated with a pronounced increase in temporo-temporal, and cingulate-temporal functional connectivity. We hypothesize that this widespread network synchronization occurs when cingulate and temporal areas coordinate their activity when more difficult social inferences are being made. SIGNIFICANCE STATEMENT Processing social information from our environment requires the activation of several brain regions, which are concentrated within the frontal and temporal lobes. However, little is known about how these areas interact to facilitate the processing of different social interactions. Here we show that functional connectivity within and between the frontal and temporal lobes is modulated by social context. Specifically, we demonstrate that viewing social interactions where the outcome was unclear is associated with increased synchrony within and between the cingulate cortex and temporal cortices. These findings suggest that the coordination between the cingulate and temporal cortices is enhanced when more difficult social inferences are being made.