Time of Day Differences in Neural Reward Functioning in Healthy Young Men
Time of Day Differences in Neural Reward Functioning in Healthy Young Men
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DOI：
10.1523/jneurosci.0918-17.2017
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发表时间：
2017-09-13
影响因子：
5.3
通讯作者：
Murray, Greg
中科院分区：
文献类型：
--
作者：
Byrne, Jamie E. M.;Hughes, Matthew E.;Murray, Greg
奖励功能似乎受到昼夜节律系统的调节，但人们对这种相互作用的神经基础知之甚少。之前的研究表明，下午的神经奖励反应可能会有所不同；然而，这种效应的方向存在争议。奖励反应可能遵循自我报告的积极情绪的昼夜节律，在下午早些时候达到顶峰。另一种选择是，每日奖励反应代表一种预测误差，神经奖励激活在一天中奖励意想不到的时候（即一天的早些时候和晚些时候）相对较高。本研究测量了健康男性男性在 10 点、14 点和 19 点进行经过验证的奖励任务时的神经奖励激活情况。感兴趣区域 BOLD fMRI 协议用于研究奖励相关大脑区域激活的昼夜波形。正如预期的那样，多级建模发现，左侧壳核存在高度显着的二次时间效应（p < 0.001）。与“预测误差”假设一致，与 14 小时相比，10 小时和 19 小时的激活显着更高。初步结论是，壳核可能在一天中不同时间奖励动机的内源性启动中特别重要，其激活模式与神经通路中昼夜节律调节的奖励预期一致（即，在一天中意想不到的时间对奖励刺激有更大的激活）。这项研究鼓励进一步研究奖励的昼夜节律调节，并强调在功能磁共振成像方案中考虑一天中的时间的方法学重要性。
Reward function appears to be modulated by the circadian system, but little is known about the neural basis of this interaction. Previous research suggests that the neural reward response may be different in the afternoon; however, the direction of this effect is contentious. Reward response may follow the diurnal rhythm in self-reported positive affect, peaking in the early afternoon. An alternative is that daily reward response represents a type of prediction error, with neural reward activation relatively high at times of day when rewards are unexpected (i.e., early and late in the day). The present study measured neural reward activation in the context of a validated reward task at 10.00 h, 14.00 h, and 19.00 h in healthy human males. A region of interest BOLD fMRI protocol was used to investigate the diurnal waveform of activation in reward-related brain regions. Multilevel modeling found, as expected, a highly significant quadratic time-of-day effect focusing on the left putamen (p < 0.001). Consistent with the "prediction error" hypothesis, activation was significantly higher at 10.00 h and 19.00 h compared with 14.00 h. It is provisionally concluded that the putamen may be particularly important in endogenous priming of reward motivation at different times of day, with the pattern of activation consistent with circadian-modulated reward expectancies in neural pathways (i.e., greater activation to reward stimuli at unexpected times of day). This study encourages further research into circadian modulation of reward and underscores the methodological importance of accounting for time of day in fMRI protocols.